愈创木酚甘油醚缓释片的制备及其体外释放度的考察  

On Preparation and in-Vitro Release of the Guaifenesin Sustained-Release Tablets

作　　者：路楠[1] 田晶晶[1] 胜芙蓉 陈一波[1] 赵宏丽[1] 

机构地区：[1]辽宁医学院药学院,辽宁锦州121001

出　　处：《辽宁医学院学报》2015年第5期1-4,111,共5页Journal of Liaoning Medical University (LNMU) Bimonthly

基　　金：2013年辽宁省"大学生创新创业训练计划"项目资助;编号:2013D25

摘　　要：目的研制愈创木酚甘油醚缓释片,并考察其体外释放度。方法以愈创木酚甘油醚为模型药物,HPMC为骨架材料,通过正交试验优选处方;以水为释放介质,采用紫外分光光度法,考察愈创木酚甘油醚缓释片的体外释放度。结果缓释片处方为:愈创木酚甘油醚40 g,HPMC 11 g,微晶纤维素15 g,聚维酮乙醇浓度为20%,硬脂酸镁1%;药物含量和体外释放度均符合规定。结论本品处方和工艺设计合理,样品释放度12 h累积释放率达到了90%以上,符合缓释片的释药要求。Objective To prepare the guaifenesin sustained - release tablets, and evaluate its release in vitro. Methods The prescription was optimized by orthogonal experiment with guaifenesin as model drug and HPMC as the skeleton material. The in - vitro release of guaifenesin sustained - release tablets was observed and analyzed by ultraviolet spectrophotometry with water as medium. Re- suits The prescription included 40 g guaifenesin, 11 g HPMC, 15 g microcrystalline cellulose, 20% povidone - ethanol solution and 1% magnesium stearate. The content and release in vitro were both up to standard. Conclusion This prescription and craft design are reasonable, and the release in vitro is accorded with the requirement of 90% cumulative release of sustained - release tablets in 12

关 键 词：愈创木酚甘油醚 缓释片 释放度 

分 类 号：R942[医药卫生—药剂学]