超声波促进合成新型吡咯α,β-不饱和酮  

Synthesis of Novel Pyrrole Derivatives with α,β-Unsaturated Ketones under Ultrasound Irradiation

作　　者：朱琰婷 单衍强 阎琨[1] 崔可可[1] 李敏[1] 王世范[1] 

机构地区：[1]海南大学海洋学院制药工程系,海南海口570228 [2]齐鲁制药(海南)有限公司,海南海口570314

出　　处：《合成化学》2015年第10期963-966,共4页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(21162006);教育部大学生创新训练项目(201410589001)

摘　　要：以乙酰乙酸酯为原料,通过亚硝化反应、Knorr缩合反应和氧化反应制得中间体3-甲基-5-甲酰基-1H-吡咯-2,4-二甲酸酯(4a^4d);在超声波促进下,4a^4d与丙酮经Aldol缩合反应合成了4个新型吡咯α,β-不饱和酮,其结构经IR,1H NMR和HR-ESI-MS表征。The intermediates,5-formyl-3-methyl-1H-pyrrole-2,4-dicarboxylic ester（ 4a - 4d）,were obtained by nitrosation,Knorr condensation and oxidization using ethyl acetoacetate and methyl acetoacetate as raw materials. Four novel pyrrole derivatives were synthesized by Aldol condensation of4 a - 4d with acetone under ultrasound irradiation. The structures were characterized by IR,1H NMR and HR-ESI-MS.

关 键 词：吡咯 Α Β-不饱和酮 超声波 合成 

分 类 号：O621.25[理学—有机化学] O626.13[理学—化学]