糖尿病肾病患者尿蛋白对糖化白蛋白的影响  

作　　者：戴静怡[1] 李声宏[1] 

机构地区：[1]苏州大学附属第一医院,215000

出　　处：《浙江临床医学》2015年第11期1856-1858,共3页Zhejiang Clinical Medical Journal

摘　　要：目的探讨糖尿病肾病患者尿蛋白对糖化白蛋白（GA）的影响。方法糖尿病肾病患者122例，其中肾病综合征患者47例，非肾病综合征患者75例，比较各组患者尿蛋白定量与GA的相关性，应用多因素回归分析影响糖尿病肾病患者GA的因素。结果GA与24h尿蛋白定量（UP）在肾病综合征组明显相关（r=-0．382，P〈0．05），在非肾病综合征组无相关性；肾病综合征组GA／糖化血红蛋白（HbAlc）水平显著低于非肾病综合征组（P〈0．05），多因素回归分析显示在肾病综合征组，仅空腹血糖（FBG）是影响GA的因素。结论肾病综合征水平的尿蛋白可以降低GA的数值，这种改变可独立于高血糖对GA的影响之外，故在使用糖化血红蛋白评估糖尿病患者血糖控制情况时，亦需考虑尿蛋白的影响。Objective To test the influence of urine protein on glycated albumin in diabetic nephrology patients. Methods A total of 122 patients were enrolled in this study, of whom 47 were nephrotic-range proteinuria.The correlation between UP and GA were examined. Results The GA and GA to HbA1 c ratio was significantly lower in nephrotic-range proteinuria than non-nephrotic-range proteinuria, while no significant difference in HbAlc or glucose levels was found.There was a signifcantly correlation between UP and GA in nephrotic-range proteinuria （ r=-0.382 , P〈0.001 ） , however no significant correlation was found in cases with non-nephrotic-range proteinuria. Conclusion Nephrotic-range proteinuria decreases GA values independent of the glycemic state, while nonnephrotic range proteinuria has no significant influence on GA values in CKD patients with diabetes.

关 键 词：慢性肾脏病 糖尿病 糖化白蛋白 

分 类 号：R726.952[医药卫生—儿科]