CRRT治疗急性重症胰腺炎并发急性肾功能衰竭的疗效观察  

作　　者：邢朝阳[1] 杨玉军[1] 

机构地区：[1]四川省广元市第一人民医院重症医学科,628000

出　　处：《浙江临床医学》2015年第11期1882-1883,共2页Zhejiang Clinical Medical Journal

摘　　要：目的观察连续肾脏替代疗法（CRRT）治疗急性重症胰腺炎并发急性肾功能衰竭的临床疗效。方法急性重症胰腺炎并发急性肾功能衰竭患者38侧，随机分为两组，观察组应用CRRT治疗，时照组应用传统血液透析治疗，比较两组临床疗效。结果观察纽APACHEII评分、Cr、Lac、CRP治疗96h后分别为（17．57±6．58）分、（199．38±13．01）μmol/L、（3．12±1．49）mmol／L、（50．99±9．05）mg／L，显著低于治疗前（P〈0．05），且与对照组治疗96h后比较明显降低（P〈0．05）；观察组去甲肾上腺素使用率及病死率分别为6例（31．58％）和2例（10．53％），均显著低于对照组（P〈0．05）。结论CRRT可有效地清除炎症介质，患者循环更稳定，病死率降低，用于急性重症胰腺炎并发急性肾功能衰竭患者具有重要意义。Objective To observe the effect of continuous renal replacement therapy （ CRRT ） for severe acute pancreatitis complicated by acute renal failure.Methods Selection of undergraduate were patients with severe acute pancreatitis complicated by acute renal failure in 38 cases as the research object were randomly divided into 2 groups, the observation group adopted the CRRT treatment, the control group adopted conventional hemodialysis treatment, compared 2 groups of clinical curative effect. Results The APACHEII score of the observation group, Cr, Lac, CRP after 96 hours of treatment were （17.57±6.58） , （199.38±13.01） umol/L, （3.12±1.49）umol/L, （50.99±9.05） mg/L-1, was significantly lower than that before treatment （ P〈0.05 ） , and the control group 96 hours after treatment, significantly reduced （ P〈0.05 ; the observation group ） norepinephrine use rate and mortality rate were 6 cases （ 31.58% ） and 2 cases （ 10.53% ） , were significantly lower than those in control group （P〈0.05） .Conclusion CRRT can effectively remove inflammatory mediators, hemodynamics more stable, lower risk of death, For the important significance in patients with severe acute pancreatitis complicated by acute renal failure.

关 键 词：连续性肾脏替代治疗 急性重症胰腺炎 急性肾功能衰竭 

分 类 号：R692.5[医药卫生—泌尿科学]