阿霉素异体脱钙骨基质骨粒骨水泥缓释体的制备及体内释药实验  

PREPARATION AND RELATED STUDY OF DECALCIFIED BONE MATRIX PARTICLES WITH ADRIAMYCIN IMPREGNATED BONE CEMENT DRUG DELIVERY SYSTEM IN VIVO

作　　者：俞玮[1] 周勇[1] 范清宇[1] 张殿忠[1] 

机构地区：[1]第四军医大学唐都医院

出　　处：《解放军医学杂志》2002年第8期683-684,共2页Medical Journal of Chinese People's Liberation Army

基　　金：第四军医大学创新工程资助课题 (编号CX99F0 1 2 )

摘　　要：为研制阿霉素异体脱钙骨基质骨粒骨水泥缓释体 ,并研究分析其体内药物释放特性 ,按Urist等的方法制备异体脱钙骨基质骨粒 ,通过冻干、真空吸附等处理 ,将阿霉素载入其中并与骨水泥按 1∶1比例复合 ,制得阿霉素异体脱钙骨基质骨粒骨水泥缓释体 ,植入家兔股骨粗隆部进行体内药物释放实验。该缓释体可使阿霉素在局部骨组织中缓慢释放达 12周以上 ,4周内维持相对稳定的水平。骨组织中最高浓度是静注相同剂量阿霉素时的 2 9倍 ,但血浆峰值浓度仅为静注组的 1/ 10 ;局部骨组织早期浓度高 ,以后为稳定的低浓度释放。提示该缓释体具有良好的缓释功能 ,能较好地满足骨肿瘤保肢术后局部化疗的要求。To prepare decalcified bone matrix particles(DBMP)with adriamycin(ADM) impregnated bone cement(BC) drug delivery system(DDS), its drug delivery characteristics were studied and analysed in vivo. DBMP were made according to the methods of Urist et al. ADM was putting into DBMP by vacuum absorption and freeze drying techniques. Then the DBMP with ADM were impregnated into BC in 1∶1 to form DDS. The DDS was implanted into the greater trochanter of femur in rabbits and the release test was done in vivo. The DDS could gradually release ADM for over 12 weeks in local bone tissues, maintained stable release for 4 weeks. The maximum ADM in local bone tissues was 29 times higher than that of the same intrarenous dose, while the maximum ADM in plasma was only 1/10 of the same intravenous dose. The DDS has a good sustained release function, and can meet the needs of local chemotherapy for limb salvage treament of bone tumor.

关 键 词：阿霉素异体脱钙骨基质骨粒骨水泥缓释体 体内释药实验 阿霉素 骨水泥 缓释体 骨肿瘤 制备方法 化疗 

分 类 号：R979.14[医药卫生—药品]