氟哌噻吨美利曲辛在难治性支气管哮喘合并负性情绪患者中的疗效研究  

Curative effect of flupenthixol melitracen on refractory asthma with negative emotion

作　　者：徐维国[1] 朱静[2] 李惠[2] 

机构地区：[1]南方医科大学珠江医院,广东广州510280 [2]四川省绵阳市中心医院呼吸内科,四川绵阳621000

出　　处：《中国现代医学杂志》2015年第25期73-77,共5页China Journal of Modern Medicine

摘　　要：目的探讨氟哌噻吨美利曲辛在难治性支气管哮喘合并负性情绪患者中的疗效。方法选取2012年6月-2014年7月该院收治的112例合并负性情绪的难治性哮喘患者为研究对象,并随机分为观察组和对照组,两组各56例。对照组给予常规内科治疗,观察组在此基础上加用氟哌噻吨美利曲辛。比较两组治疗前后的汉密尔顿焦虑量表(HAMA)评分、汉密尔顿抑郁量表(HAMD)评分、哮喘控制测试量表(ACT)评分、第1秒用力呼气容积占预计值百分比(FEV1%pre)及呼气峰流量(PEF)。结果治疗后第2和4周,观察组的HAMA和HAMD评分均显著低于对照组,ACT评分、FEV1%pre和PEF均显著高于对照组(P<0.05)。结论难治性哮喘常合并焦虑、抑郁等负性情绪,在常规治疗基础上联用氟哌噻吨美利曲辛可显著改善患者的负性情绪,提高哮喘症状的控制效果,改善肺功能,值得临床推广应用。【Objective】To investigate the curative effect of flupenthixol melitracen on refractory asthma with negative emotion. 【Methods】A total of 112 refractory asthma patients with negative emotion from June 2012 to July2014 were enrolled in the study and randomly divided into the observation group and the control group, with 56 cases in each group. Patients in the control group were given conventional treatment. Based on it, cases in the observation group were given flupenthixol melitracen. The scores of Hamilton Anxiety Scale（HAMA）, Hamilton Depression Scale（HAMD）, asthma control test（ACT）, FEV1%pre and PEF were compared between two groups.【Results】Compared with the control group, the scores of HAMA and HAMD were all significantly lower, and the ACT score,FEV1%pre and PEF were all significantly higher in the observation group（P〈0.05）.【Conclusions】Refractory asthma is often associated with anxiety, depression and other negative emotions. Flupenthixol melitracen combined with conventional treatment could significantly improve negative emotions, asthma symptoms and lung function, which is worthy of clinical promotion.

关 键 词：氟哌噻吨美利曲辛 难治性哮喘 焦虑 抑郁 

分 类 号：R562.25[医药卫生—呼吸系统]