细菌sRNA对环境胁迫的响应机制  

The mechanism of small RNAs response to environmental stresses in bacteria

作　　者：刘福芮 钟志军[1] 周紫峣[1] 彭广能[1] 杨平 王亚萍 廖莉 

机构地区：[1]四川农业大学动物医学院,四川成都611130 [2]四川省雅安市名山区农业局,四川雅安625100

出　　处：《微生物学通报》2015年第10期2012-2018,共7页Microbiology China

基　　金：四川省科技厅科技支撑项目(No.2011NZ0060);国家自然科学基金项目(No.31272620);农业部公益性行业项目(No.201303042)

摘　　要：细菌小RNA(small RNAs,sRNAs)是一类长度大约在40-400个核酸之间,不编码蛋白质的RNA,在细菌适应环境方面起重要的调节作用。当环境中温度、营养、外膜蛋白、p H、铁等条件改变时,sRNA常常通过连接双组分信号转导系统和调节蛋白,来传递压力信号并调节应激响应,其作用方式一般是通过碱基互补配对的方式与靶m RNA结合,从而调控靶m RNA的翻译和稳定性;或直接与靶标蛋白质结合,调节靶标蛋白质的生物活性。本文总结了细菌在多种环境压力下,sRNA的调控响应机制。Small RNAs in bacteria is a kind of 40-400 nt non-coding RNAs which play an important role in regulation while the environmental conditions （such as temperature, nutrition, outer membrane protein, pH and iron） change. Small RNAs generally transport environmental stress signals and stress responses through the two component signal system and regulatory proteins, and play functions via antisense base pairing with target mRNAs to regulate translation and degradation of target mRNA, or via directly binding proteins and then modulating their activities. This paper reviewed the regulation roles and the response mechanism of sRNAs in bacteria in different stress.

关 键 词：细菌 sRNAs 环境胁迫 响应机制 

分 类 号：Q935[生物学—微生物学]