乙交酯精制的研究进展  

Research progress in glycolide purification

作　　者：朱煜 王睿 田鹏飞 周文乐 

机构地区：[1]上海石油化工研究院,上海201263

出　　处：《合成纤维工业》2015年第5期43-46,共4页China Synthetic Fiber Industry

摘　　要：乙交酯是制备可降解手术缝合线材料聚乙醇酸和聚乙丙交酯的单体,乙交酯的精制是制备高相对分子质量聚乙醇酸以及聚乙丙交酯的关键。介绍了乙交酯的精制方法及各自的优缺点,并对乙交酯精制方法的工业化应用提出了建议。乙交酯精制方法主要包括溶剂重结晶法、溶剂萃取法、熔融结晶法和耦合法,其中熔融结晶法由于不使用有机溶剂且能耗低,具有较好的工业化应用前景;今后的研究重点是改进乙交酯的制备工艺,尽可能减少其杂质含量,通过熔融结晶法和其他精制方法相结合,以获得更好的精制效果。Glycolide is the monomer for polyglycolic acid and poly （glycolide lactide ） , degradable surgical suture materials. Glycolide purification is the key to the preparation of high-relative molecular mass polyglycolic acid and poly（ glycolide lactide）. The purification methods for glycolide were introduced, including solvent recrystallization, solvent extraction, melt crystallization and coupling method, and their advantages and disadvantages were compared. The industrial application of glycolide purification methods was suggested. The melt crystallization was expected to be of the most promised industrial application prospects due to solvent free and low energy consumption. The research in the future should be focused on the improvement of glycolide prepara- tion process in order to reduce the impurities content as musch as possible and the combination of melt crystallization and other purification methods in order to acquire better purification effect.

关 键 词：乙交酯 聚乙丙交酯 精制 溶剂重结晶 熔融结晶法 溶剂萃取 耦合 

分 类 号：TQ225.24[化学工程—有机化工]