丹红注射液对急性缺血性脑卒中患者神经功能及血液流变学的影响  

Effect of Danhong Injection on Nerve Function and Hemorheology for Patients with Acute Ischemic Stroke

作　　者：马进[1] 余能伟[1] 武航海[1] 陈岷[1] 任智文[1] 赵东东[1] 

机构地区：[1]四川省人民医院,成都610072

出　　处：《中国实验方剂学杂志》2015年第20期204-207,共4页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:探讨中药丹红注射液在急性缺血性脑卒中患者中的临床应用价值和意义。方法:选取2013年6月—2014年6月期间本院收治的急性缺血性脑卒中患者90例,将其随机分为研究组和对照组,每组45例。对照组患者给予脱水降颅压、抗血小板聚集、脑保护剂等一般常规治疗方案,研究组患者则在对照组基础上采用中药丹红注射液的临床药物治疗,分别比较和分析两组患者的神经功能恢复情况、血液流变学变化情况及日常生活能力改善情况。结果:与对照组相比,研究组患者神经功能显著进步的比率46.67%(21/45)和总有效率91.11%(41/45)均显著提高,并且两组间比较差别均具有统计学意义(P<0.05);研究组患者治疗后血浆黏度(1.39±0.21)m Pa·s,全血黏度高切值(5.91±0.12)m Pa·s,全血黏度低切值(7.18±1.34)m Pa·s,红细胞压积(40.23±4.15)%,血小板黏附率(26.73±5.24)%等血液流变学指标均显著降低,并且两组间比较差别均具有统计学意义(P<0.05);研究组患者治疗后BI评分值(74.61±7.82)分和FMA评分值(54.88±5.36)分均显著提高,并且两组间比较差别均具有统计学意义(P<0.05)。结论:中药丹红注射液对于急性缺血性脑卒中患者神经功能的恢复,血液流变学的改善以及日常生活能力的提升均具有极其重要的临床治疗意义,值得进一步的应用和推广。Objective： To probe into clinical application value and significance of Danhong injection for patients with acute ischemic stroke. Method： Totally 90 acute ischemic stroke patients treated in our hospital From June 2013 to June 2014 were selected. The patients were divided into study group and control group randomly.There were 45 cases in each group. The patients in control group were treated with conventional regimen,including lowering the intracranial pressure,anti-platelet aggregation and neuroprotective agents. The patients in study group were treated with Danhong injection in addition to the therapies in control group. The neurological recovery,changes of hemorheology and improvements in activities of daily living of the patients in two groups were compared and analyzed. Result： Compared with control group,the patients in study group showed significant increases in the ratio of neurological improvement at 46. 67%（ 21 /45） and total efficiency at 91. 11%（ 41 /45）,the differences were significant statistically（ P〈0. 05）. Compared with control group,after treatment,the patients in study group showed significant decreases in the plasma viscosity at（ 1. 39 ± 0. 21） m Pa·s,whole blood viscosity at high shear value at（ 5. 91 ± 0. 12） m Pa·s,whole blood viscosity at low shear value at（ 7. 18 ± 1. 34） m Pa·s,hematocrit at（ 40. 23 ± 4. 15） %,platelet adhesion rate at（ 26. 73 ± 5. 24） %,the differences were significant statistically（ P〈0. 05）. Compared with control group,after treatment,the patients in study group showed significant increases in BI scores at（ 74. 61 ± 7. 82） points and FMA scores at（ 54. 88 ± 5. 36） scores,the differences were significant statistically（ P〈0. 05）. Conclusion： Danhong injection has extremely important clinical significance in recovering nerve function,improving hemorheology and enhancing daily living for patients with acute ischemic stroke. It was worth further applying and promoting.

关 键 词：急性缺血性脑卒中 丹红注射液 神经功能 血液流变学 

分 类 号：R287.6[医药卫生—中药学]