茵陈水提物对镉中毒所致小鼠肝氧化应激的保护作用  

Protective effect of Artemisia capillaris aqueous extract on oxidative stress in mice liver induced by Cadmium poisoning

作　　者：李瑾[1] 白峰[2] 

机构地区：[1]山西农业大学动物科技学院,山西太谷030801 [2]山西农业大学研究生学院,山西太谷030801

出　　处：《中兽医医药杂志》2015年第5期54-56,共3页Journal of Traditional Chinese Veterinary Medicine

基　　金：自选项目

摘　　要：目的:观察茵陈水提物对镉中毒所致小鼠肝脏氧化应激的保护作用。方法:将实验小鼠随机分为对照组,镉中毒组,茵陈水提物高、低剂量组。镉中毒组采用饮水染毒(氯化镉浓度为50 mg/L),茵陈水提物高、低剂量组(40 m L/kg、20 m L/kg)均以灌胃给药,1次/d,30 d后采样检测小鼠血清中谷丙转氨酶(ALT)和谷草转氨酶(AST)的活力以及肝组织中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、谷胱甘肽(GSH)活力和丙二醛(MDA)含量。结果:茵陈水提物可明显降低镉中毒小鼠血清中ALT和AST活力,增强镉中毒小鼠肝组织中SOD、GSH-Px、GSH的活力,并降低MDA含量。结论:茵陈水提物可抑制镉中毒所致小鼠肝脏的氧化应激,对镉中毒所致小鼠肝损伤有保护作用。Objective： To observe the protective effect of Artemisia capillaris aqueous extract on oxidative stress in mice liver which caused by Cadmium poisoning. Methods： 40 mice were randomly divided into control group, Cadmium poisoning group（the concentration of Cadmium Chloride was 50 mg/L in drinking water）, Artemisia capillares aqueous extract group（dosage of40 mg/L and 20 mg/L, intragastric administration once daily）. All mice were killed after 30 days, the blood and liver were sampled to measure the level of glutamic-pyruvic transaminase（ALT） and aspartate aminotransferase（AST） in serum, and the contents of superoxide dismutase（SOD）, Glutathione peroxidase（GSH-Px）, Glutathione（GSH） and Malondialdehyde（MDA） in liver. Results： Artemisia capillaries aqueous extract could obviously decrease the activity of ALT and AST in serum, increase the level of SOD, GSH-Px, GSH and decrease MDA content in liver tissue of mice with chronic Cadmium poisoning.Conclusion： Artemisia capillaries aqueous extract can inhibit oxidative stress of mice liver and protect it from hepatic injury caused by Cadmium poisoning.

关 键 词：茵陈水提物 镉中毒 氧化应激 小鼠 

分 类 号：S859.82[农业科学—临床兽医学]