慢性阻塞性肺疾病稳定期中医证型与肺功能的关系探讨  

Cross-sectional Study on the Relationship between Syndromes of Traditional Chinese Medicine and Lung Function in Patients with Chronic Obstructive Pulmonary Disease at Stable Phase

作　　者：瞿波[1] 周维[1] 毛兵[1] 

机构地区：[1]四川大学华西医院中西医结合科,成都610041

出　　处：《华西医学》2015年第10期1853-1856,共4页West China Medical Journal

摘　　要：目的探讨慢性阻塞性肺疾病(COPD)稳定期患者中医证候分型与肺功能的关系。方法 2010年3月-2011年2月期间,收集在四川大学华西医院中西医结合科及呼吸内科COPD专病门诊就诊病例,根据权威的COPD稳定期中医证候参考标准,确立5组虚证证型(肺气虚、肺脾气虚、肺肾气虚、肺脾肾气虚及气阴两虚),收集符合纳入标准的COPD稳定期患者每种证型各60例,共收集病例300例。调查其一般资料及肺功能指标,统计分析各证型之间肺功能指标的差异。结果各证型组患者第1秒用力呼气量由高到低依次是:肺气虚组>肺脾气虚组>肺肾气虚组>肺脾肾气虚组、气阴两虚组,差异有统计学意义(P<0.05)。结论随证型由肺气虚→肺脾气虚、肺肾气虚→肺脾肾气虚、气阴两虚发展,患者肺功能进行性下降,肺功能检查有助于揭示COPD稳定期患者中医证型的实质和病机,为临床辨证提供依据。Objective To investigate the relationship between syndromes of traditional Chinese medicine（TCM） and lung function in patients with chronic obstructive pulmonary disease（COPD） at stable phase. Methods Based on diagnostic criterion of TCM, five groups of symptoms of TCM about stable COPD were established including lung Qi deficiency, lung and spleen Qi deficiency, lung and kidney Qi deficiency, lung Spleen Kidney Qi deficiency, and deficiency of both Qi and Yin. A total of 300 cases which were up to the standard were differentiated into 5 groups by the symptoms. Some basic details and lung function of the patients were recorded, and then statistical analysis was performed to analyze the differences of lung function among groups. Results Forced expiratory volume in the first second in descending order was lung Qi deficiency group, lung and spleen Qi deficiency group, lung and kidney Qi deficiency group, and lung spleen kidney Qi deficiency group（P〈0.05）. Conclusions These findings suggest that with the progressing of COPD, the symptom type of TCM for COPD patients at stable phase may vary from lung Qi deficiency to lung and spleen Qi deficiency, or to lung and kidney Qi deficiency, and even lung, spleen and kidney Qi deficiency. Lung function tests help reveal substance and pathogenesis of TCM syndromes of patients with stable COPD, and provide evidence for the clinical syndrome.

关 键 词：慢性阻塞性肺疾病 稳定期 中医证型 肺功能 

分 类 号：R259[医药卫生—中西医结合]