超声标准化定量评价糖尿病患者左心构型变化  

Standardized quantitative evaluation on the left ventricular geometry change in diabetics using echocardiography

作　　者：吴晶晶[1] 朱向明[1] 李竹琴[1] 

机构地区：[1]皖南医学院第一附属医院弋矶山医院超声医学科,安徽芜湖241001

出　　处：《皖南医学院学报》2015年第5期479-482,共4页Journal of Wannan Medical College

基　　金：安徽省科技攻关项目(1301042203)

摘　　要：目的：通过体表面积对左心构型超声指标进行标化,观察标化前、后各项指标在空腹血糖受损组及糖尿病组的变化;并将标化前后指标对比分析,初步探讨标化前、后指标反映左心构型变化的敏感性。方法：于我院2012年1月~2013年12月门诊及住院糖尿病病人中选择80例患者,按1999年WHO规定的糖尿病的诊断标准分成两组：空腹血糖受损组及糖尿病组。于我院健康体检中心选择20例研究对象为正常对照组。心电触发二维切面超声于心脏舒张期末测量超声参数,将这些参数用体表面积标化,一方面观察标化前后各项指标随血糖升高发生的变化,另一方面将标化前后指标对比,通过统计学处理分析,观察标化前后指标在反映血糖升高对左心构型的改变方面的敏感性和稳定性。结果：上述标化前后各项指标均值在空腹血糖受损组及糖尿病组逐渐增大,其中标化前空腹血糖受损组各项指标与正常对照组之间的差异无显著性（P〉0.05）,标化后与正常对照组之间的差异有显著性（P均〈0.01）;糖尿病组各项指标标化前后与对照组之间的差异均有显著性（P均〈0.01）;标化前后各项指标在空腹血糖受损组及糖尿病组之间的差异亦有显著性（P均〈0.01）。结论：随着血糖的升高,左心构型标化前指标（LVPWT、LVM、LAA、LVV）除LVEDd外及标化后指标（LVEDdi、LVPWTi、LVMi、LAAi、LVVi）逐渐增大;标化后指标可以更敏感地反映糖尿病患者左心构型的改变。Objective ： To preliminarily evaluate the sensitivity of the indicators before and after quantitative standardization to the variation of the cardiac configuration in patients with diabetes mellitus. Methods ： Eighty clinical patients or inpatients with diabetes mellitus（DM） were included through January 2012 to December 2013, and allocated to group of impaired fasting glucose and diabetics in compliance with the 1999 WHO criteria for DM, and another 20 healthy subjects from our physical examination center were volunteer as normal controls. Electrocardiography（ECG） -gated two-dimensional data at the end- diastolic phase were acquired to measure the ultrasound parameters that were used to standardize the body surface area. Each indicator was observed con- cerning the changes to the elevated glucose level in relation with the cardiac geometry, and statistically evaluated before and after standardization. Results： No statistical difference was found in parameters before standardization between the control group IFG group （ P 〉 0.05 ） ,yet the indicators after standardi- zation were obviously different between the controls and IFG group （P 〈 0. 01 ）. The indicators before and after standardization were totally different be- tween the controls and patients with diabetes mellitus, as well as IFG patients and diabetics. The variation coefficient for the indicators after standardization was less than that before standardization. Conclusion ： All indicators before and after standardization of left ventricular geometry tend to increase with eleva- tion of the blood sugar except LVEDd, suggesting that these indicators after standardization may sensitively reveal the changes of cardiac geometry in pa-tients with diabetes mellitus.

关 键 词：超声心动图 实时三维超声 糖尿病 构型 标化 

分 类 号：R445.1[医药卫生—影像医学与核医学]