人参二醇组皂甙及游泳训练对大鼠股四头肌α-肌动蛋白mRNA表达的影响  

Effects of prolonged heavy load swimming and the Panaxadiol saponins on expression of α-actin of quadriceps in rats

作　　者：杨柯[1] 赵丹[1] 李峰[1] 王志农[1] 赵雪俭[1] 陈燕萍[2] 马兴元[2] 

机构地区：[1]吉林大学基础医学院生殖病生研究室,吉林长春130021 [2]吉林大学基础医学院天然药物化学研究室,吉林长春130021

出　　处：《中国病理生理杂志》2002年第8期942-945,共4页Chinese Journal of Pathophysiology

基　　金：卫生部科研基金资助项目 (No.98-2- 182)

摘　　要：目的 :观察大鼠 7周大负荷游泳训练及人参二醇组皂甙 (PDS)对大鼠股四头肌α -肌动蛋白mRNA表达的影响。方法 :采用Northernblot分析 7周大负荷游泳训练后恢复期大鼠股四头肌α -肌动蛋白mRNA表达水平及PDS对其影响。结果 :α-肌动蛋白mRNA杂交信号的扫描积分光密度值 (A) ,运动·盐水组较安静组略强 ;运动·PDS,扫描积分光密度值 (A)显著强于运动·盐水组和安静组 ,运动·甲睾组与运动·盐水组表达无明显差异。结论 :PDS可提高长期耐力运动大鼠股四头肌α -肌动蛋白mRNA表达 ,从而提高耐力运动能力 ;长期应用外源性雄激素对耐力训练大鼠股四头肌α -肌动蛋白无明显提高 ,这可能与外源睾酮对内源性睾酮分泌的抑制有关。AIM: To study the effects of 7 weeks prolonged haevy load swimming and Panaxadiol Saponins (PDS) on the expression of α-actin in quadriceps muscle of thigh in rats. METHODS: After 7 weeks prolonged heavy load swimming training, the expression of α-actin in quadriceps muscle of thigh was quantitatively examined by Northern blotting analysis in the condition with or without PDS treatment. RESULTS: The expression of α-actin in rat quadriceps muscle of thigh in exercise+PDS group was significantly higher than that in sedentray control group and exercise+saline group at 24 th hour after intensive training. No statistical difference between exercise+androsan group and exercise+saline group was observed.CONCLUSION: PDS enhanced α-actin expression in quadriceps muscle of thigh in rats.

关 键 词：人参二醇组皂甙 游泳训练 股四头肌 耐力运动 肌蛋白质类 过度训练 

分 类 号：G804.2[文化科学—运动人体科学] R965[文化科学—体育学]