补肾疏肝汤对大鼠抗疲劳作用的机理  

Action Mechanism of Antifatigue of Kidney-Tonifying and Liver-Soothing Decoction in Rats

作　　者：牛占忠[1] 张喜平[1] 周红军[1] 侯玉茹[1] 

机构地区：[1]沧州医学高等专科学校,河北沧州061000

出　　处：《河南中医》2015年第9期2047-2048,共2页Henan Traditional Chinese Medicine

基　　金：沧州市科学技术研究与发展指导计划项目(编号:1123079ZD)

摘　　要：目的:探讨补肾疏肝汤对大鼠抗疲劳作用的机理。方法:选择雄性健康SD大鼠50只,随机分为五组:空白对照组,模型对照组,补肾疏肝汤低剂量组,补肾疏肝汤中剂量组,补肾疏肝汤高剂量组,每组10只。除空白对照组外,其余各组每天行一次力竭游泳,同时连续灌胃14d后,主动脉取血观察血清LDH、LD、CK、BUN变化情况。结果:补肾疏肝汤低剂量组、补肾疏肝汤中剂量组、补肾疏肝汤高剂量组大鼠血清LDH、LD、CK、BUN值均下降,且优于空白对照组、模型对照组(P<0.05或P<0.01)。结论:补肾疏肝汤能通过调整血LDH、LD、CK、BUN值而起到抗疲劳作用。Objective： To discuss the action mechanism of antifatigue of Kidney-Tonifying and Liver-Soothing Decoction in rats.Methods： 50 male healthy SD rats were selected and randomized into five groups： blank control group,model control group,low dosage group of Kidney-Tonifying and Liver-Soothing Decoction,medium dosage group of Kidney-Tonifying and Liver-Soothing Decoction and high dosage group of Kidney-Tonifying and Liver-Soothing Decoction,with 10 rats in each group. Except for blank control group,the rest of the groups were performed exhausted swimming and given continuous gavage for 14 d,and the blood was taken from the aorta to observe the changes of LDH,LD,CK and BUN. Results： the values of LDH,LD,CK and BUN in low,medium and high dosage group of Kidney-Tonifying and Liver-Soothing Decoction all decreased,better than blank control group and model control group（ P 〈0. 05 or P〈 0. 01）. Conclusion： Kidney-Tonifying and Liver-Soothing Decoction achieves antifatigue function through regulating the values of LDH,LD,CK and BUN.

关 键 词：补肾疏肝汤 抗疲劳 乳酸脱氢酶 乳酸 尿素氮 肌酸激酶 大鼠 

分 类 号：R285.5[医药卫生—中药学]