马尾松松针中木脂素苷的分离与结构鉴定  

ISOLATION AND STRUCTURE IDENTIFICATION OF LIGAN GLYCOSIDES FROM PINE NEEDLES OF PINUS MASSONIANA LAMB

作　　者：毕跃峰[1] 郑晓珂[1] 冯卫生[1] 张勇忠[1] 冀春茹[1] 

机构地区：[1]河南中医学院,河南郑州450008

出　　处：《药学学报》2002年第8期626-629,共4页Acta Pharmaceutica Sinica

基　　金：河南省首届高校杰出科研人才创新工程基金资助项目 (2 0 0 0KYCX0 0 6)

摘　　要：目的　研究松科 (Pinaceae)植物马尾松 (PinusmassonianaLamb .)松针 (pineneedles)的化学成分。方法　利用DIAIONHP 2 0 ,TOYOPEARLHW 4 0等色谱技术分离纯化 ,根据化合物的理化性质和光谱数据 (UV ,IR ,MS ,1 H 1 HCOSY ,HMQC ,DEPT ,HMBC和ORD等 )进行结构鉴定。结果　从马尾松松针水煎液的正丁醇萃取部位分离得到 3个化合物 ,分别鉴定为化合物 4 (massonianosideA) :(7S ,8R) 3,4 ,9′ 三羟基 3 甲氧基 7,8 二氢苯并呋喃 1′ 丙醇基新木脂素 9 O α L 鼠李糖苷 ;化合物 5 (massonianosideC) :(7S ,8R) 9,9′ 二羟基 3,3′ 二甲氧基 7,8 二氢苯并呋喃 1′ 丙醇基新木脂素 4 O α L 鼠李糖苷 ;化合物 6 (cedrusin 4 O β glucoside) :(7S ,8R) 3,9,9′ 三羟基 3 甲氧基 7,8 二氢苯并呋喃 1′ 丙醇基新木脂素 4 O β D 葡糖苷。 结论　化合物 4和AIM To study the chemical constituents of the pine needles of Pinus massoniana lamb.. METHODS Various chromatographic techniques were used to separate and purify. Their physico chemical properties and spectral data (UV, IR, MS, 1H 1H COSY, HMQC, DEPT, HMBC and ORD ect.) were measured for structure elucication. RESULTS Three compounds were isolated from the n BuOH fraction of water extracts. Their structures were identified as massonianoside A (4), massonianoside A: (7 S ,8 R ) 3,4,9′ trihydroxyl 3 methyoxyl 7,8 dihydrobenzofunan 1′ propanolneoligan 9 O α L rhamnopyranoside, massonianoside C (5), (7 S ,8 R ) 9,9′ dihydroxyl 3,3′ dimethyoxyl 7,8 dihydrobenzofunan 1′ propanolneoligan 4 O α L rhamnopyranoside and cedrusin 4 O β glucoside (6), (7 S ,8 R ) 3′,9,9′ trihydroxyl 3 methoxyl 7,8 dihydrobenzofunan 1′ propanolneoligan 4 O β D glucopyranoside. CONCLUSION Compound 4 and 5 are new compounds.

关 键 词：松针 木脂素苷 结构鉴定 马尾松 massonianoside A massonianoside C 成分分离 

分 类 号：R284[医药卫生—中药学]