桑黄菌丝体对H22荷瘤小鼠肿瘤生长的影响  

Effect of Phellinus ignairius mycelia on tumor growth of H22 tumor-bearing mice

作　　者：雷萍[1] 吴亚召[1] 张文隽[1] 宋延平[2] 杜芳[1] 杨洁[2] 谢婷婷[2] 李玲梅[2] 

机构地区：[1]陕西省微生物研究所,陕西西安710043 [2]陕西省中医药研究院,陕西西安712000

出　　处：《西北大学学报（自然科学版）》2015年第5期773-776,共4页Journal of Northwest University（Natural Science Edition）

基　　金：陕西省科技厅农业攻关计划基金资助项目(2013K01-22);陕西省自然科学基础研究计划基金资助项目(2013JM3021);陕西省科学院重点项目与产业化专项基金资助项目(2013K-03)

摘　　要：观察桑黄菌丝体对荷H22小鼠实体瘤生长的影响,探讨其抑瘤作用。采用小鼠移植瘤模型,随机分为5组,分别为荷瘤对照组、环磷酰胺对照组、桑黄菌丝体6.0 g/kg,3.0g/kg,1.5 g/kg剂量组,灌胃给药10 d后对荷瘤小鼠瘤重进行测量。桑黄菌丝体6.0,3.0,1.5 g/kg剂量对荷H22小鼠实体瘤3批小鼠的平均抑瘤率分别为43.6%,36%,26%。结果表明该品6.0,3.0 g/kg剂量组3批试验对荷H22小鼠实体瘤的平均抑瘤率达到30%以上,且重复性良好,说明桑黄菌丝体具有明显的抑瘤作用。To observe the effect of Phellinus ignairius mycelia on the growth of H22 solid tumor bearing mice,to investigate the antitumor effect of this product. Using a mouse xenograft model,the mice were randomly divided into 5 groups： tumor control group,cyclophosphamide group,Phellinus mycelium of 6. 0g / kg,3. 0g /kg,1. 5g / ㎏ dose group. By oral administration to mice bearing tumor for 10 days,their weight was measured.The average inhibition rates of 6. 0,3. 0,1. 5g / kg dose on H22 solid tumor bearing mice were 43. 6%,36%,26%. The results showed that for the 6. 0,3. 0g / kg dose group,3 batch test on H22 solid tumor bearing mice,the average inhibition rate reached more than 30%,and well repeatability,which showed that Phellinus ignairius mycelia had obvious anti-tumor effect.

关 键 词：桑黄 菌丝体 H22荷瘤小鼠 肿瘤作用 

分 类 号：R285.5[医药卫生—中药学]