重型乙型肝炎并发医院感染的相关因素分析  

Analysis of related factors and nursing countermeasure of severe hepatitis B complicated with nosocomial infection

作　　者：吴芬[1] 刘赟[1] 夏余群[1] 涂建飞[2] 

机构地区：[1]浙江省丽水市中心医院感染科,浙江丽水323000 [2]浙江省丽水市中心医院影像诊断与介入放射科,浙江丽水323000

出　　处：《中国现代医生》2015年第29期15-17,共3页China Modern Doctor

基　　金：浙江省科技计划项目(2010C33113)

摘　　要：目的探讨重型乙型肝炎并发医院感染的相关危险因素及改善预后。方法回顾性分析2012年1月-2014年6月116例重型乙型肝炎患者的临床资料，比较感染组与非感染组的相关因素，并进行Logistic回归分析。结果发生医院感染48例，医院感染发生率为41．38％（48／116）。Logistic回归分析显示医院感染与住院时间（OR=1．992．95％CI1．687～2．352）、应用激素及免疫抑制剂（OR=2．063，95％CI1．721～2．473）、抗菌药物使用种类（OR=1．856．95％CI1．569～2．195）、侵袭性操作（OR=1．998：95％CI1．627～2．454）、合并并发症（OR=2．152，95％CI1．694～1．463）、抑郁（OR=1．821，95％CI1．628～2．037）和血清白蛋白（OR=2．352，95％CI1．884～2．936）有关。结论重型乙型肝炎患者医院感染发生率高，且与多种危险因素有关。Objective To study the related factors for severe hepatitis B complicated with nosoeomial infection and im- prove prognosis. Methods The clinical data of 116 patients with severe hepatitis B infection were retrospectively ana- lyzed from Jan 2012 to Jun 2014. The related factors were compared between the infected group and non-infected group, and tested by Logistic regression analysis. Results The nosocomial infection incidence was 41.38% （48/116）. Lo- gistic regression analysis showed that nosocomial infection related to length of hospital stay （OR=1.992, 95%CI 1.687- 2.352）, the hormone and immune inhibitors（OR=2.063, 95%CI 1.721-2.473）, antimicrobial drug use （0R=1.856, 95%CI 1.569-2.195）, invasive operation（OR=1.998, 95%CI 1.627-2.454）, merging complications （0R=2.152, 95%CI 1.694- 1.463）, depression （0R=1.821, 95%CI 1.628-2.037） and serum albumin （0R=2.352, 95%CI 2.352-2.352）. Conclusion The patients with severe hepatitis B lead to a high incidence of nosocomial infection, and is associated with a variety ofrisk factors.

关 键 词：重型肝炎 乙型肝炎 医院感染 危险因素 

分 类 号：R512.6[医药卫生—内科学]