替格瑞洛和辛伐他汀早期联合治疗不稳定性心绞痛疗效观察  

Observation of the clinical therapeutic effect of ticagrelor and simvastatin in the early treatment of unstable Angina

作　　者：曾育辉[1] 张凡[1] 杨贞文[1] 梁秋玲[1] 曾智恒[1] 

机构地区：[1]广东药学院附属第一医院急诊科,广东广州510080

出　　处：《中国现代医生》2015年第29期79-81,85,共4页China Modern Doctor

摘　　要：目的观察替格瑞洛和辛伐他汀早期联合治疗不稳定性心绞痛的临床疗效。方法选择2014年1月～2015年5月在本院就诊的78例不稳定性心绞痛患者，随机分为治疗组（n=40）、对照组（n=38）。两组均常规应用硝酸酯类、β-受体阻滞剂和阿司匹林等药物治疗，治疗组予替格瑞洛和辛伐他汀治疗。随访3个月，观察两组的临床疗效和主要心脏不良事件。结果治疗组治疗有效率92．50％，对照组治疗有效率71．05％，两组比较差异有统计学意义（P〈0．05）；治疗组主要心脏不良事件发生率12．50％，对照组主要心脏不良事件发生率28．95％，两组比较差异有统计学意义（P〈0．05）。结论替格瑞洛和辛伐他汀早期联合治疗不稳定性心绞痛可明显提高治疗有效率，减少主要心脏不良事件的发生。Objective To observe the clinical therapeutic effect of ticagreclor and simvastatin in the early treatment of unstable angina. Methods A total of 78 unstable angina patients admitted in the first affiliated hospital of Guangdong Pharmaceutical University from January 2014 to May 2015 were randomly divided into treatment group（n=40） and con- trol group（n=38）. Two groups were given drugs of nitrates,beta-blocker and aspirin. While the treatment group was ad- ditional treated with ticagreclor and simvastatin. After three months follow-up, the clinical therapeutic effect and the events of major adverse cardiac were observed in both groups. Results For the treatment group and the control group, the improvement of clinical therapeutic effect was（92.50% vs 71.05%,P〈0.05）. The events of major adverse cardiac was significant （12.50% vs 28.95%,P〈0.05）. Conclusion Associated with ticagreclorl and simvastatin to early treat unstable angina can improve the clinical therapeutic effect and decrease the major adverse cardiac events significantly.

关 键 词：替格瑞洛 辛伐他汀 不稳定性心绞痛 

分 类 号：R541.4[医药卫生—心血管疾病]