不同雌激素添加方案对氯米芬促排卵周期子宫内膜的影响  

Different estrogen adding scheme in ovulation induction cycle endometrial effects on clomiphene citrate

作　　者：俞飞[1] 

机构地区：[1]高邮市妇幼保健所,江苏高邮225600

出　　处：《基层医学论坛》2015年第29期4038-4039,共2页The Medical Forum

摘　　要：目的比较不同雌激素添加方案对氯米芬促排卵周期子宫内膜的影响。方法分析排卵障碍的不孕症患者30例,在氯米芬促排卵周期最大卵泡平均直径达18 mm^20 mm时,子宫内膜厚度<7 mm共48个周期,按不同的雌激素添加方案分为2组,A组为氯米芬加戊酸雌二醇常规方案;B组在常规方案基础上,最大卵泡平均直径达18 mm^20 mm时给予戊酸雌二醇8 mg^10 mg顿服,余同A组。观察排卵后子宫内膜厚度、排卵率和妊娠率。结果肌肉注射h CG后48 h子宫内膜厚度比较,B组子宫内膜比A组厚,差异有统计学意义(P<0.05),2组的排卵率和周期妊娠率差异有统计学意义(P<0.05)。结论在氯米芬促排卵方案中,卵泡成熟时薄型子宫内膜者,给予大剂量雌激素顿服,改善子宫内膜,有助于排卵及胚胎着床,提高妊娠率,值得临床推广。Objective Retrospective analysis of clomiphene citrate（CC）to monitor follicular ovulation cycle data,Comparing the different effects of estrogen adding scheme promoting ovulation of clomiphene endometrium.Method Analysis of 30 cases of ovulatory disorder infertility patients,In the clomiphene citrate ovulation cycle maximum follicle average diameter of 18 ～ 20mm,Endometrial thickness 〈7mm a total of 48 cycle,According to the different estrogen add scheme is divided into 2 groups,group A as the chlorine plus estradiol valerate conventional scheme; B group in the conventional scheme,the biggest follicle average diameter of 18 ～ 20mm when given estradiol valerate 8 ～ 10mg meal served,Remaining the same as A group. Observation after ovulation,endometrial thickness,the ovulation rate and pregnancy rate.Results Comparison of 48 hours of endometrial thickness muscles after injection of hCG,B group than A group,endometrial thickness,the difference was statistically significant（P〈0.05）,ovulation rate and the pregnancy period two group there were significant differences（P〈0.05）.Conclusion In the clomiphene citrate ovulation induction scheme,follicular maturation when thin endometrium,high-dose estrogen orally,improve the endometrial,help ovulation and embryo implantation,improve the pregnancy rate,is worth the clinical promotion.

关 键 词：氯米芬 雌激素 促排卵 子宫内膜 妊娠率 

分 类 号：R714.8[医药卫生—妇产科学]