腹腔镜胆囊切除术前给予帕瑞昔布钠对患者苏醒期躁动、疼痛及血流动力学的影响  

Effect of treatment of parecoxib sodium before laparoscopic cholecystectomy on the patients' dysphoria,pain and hemodynamic stability during recovery period

作　　者：祖翠华[1] 

机构地区：[1]徐州市中心医院麻醉科,江苏徐州221009

出　　处：《新乡医学院学报》2015年第9期884-886,共3页Journal of Xinxiang Medical University

摘　　要：目的探讨术前给予帕瑞昔布钠对腹腔镜胆囊切除患者术后躁动、疼痛及血流动力学的影响。方法选择全身麻醉下行腹腔镜胆囊切除术患者80例分为观察组和对照组,每组40例。观察组患者术前20 min给予40 mg帕瑞昔布钠静脉注射,对照组患者给予等量生理盐水。比较2组患者术后不同时间的心率（HR）、平均动脉压（MAP）、疼痛评分（VAS）、躁动评分及不良反应发生率。结果 2组患者的出血时间、拔管时间、麻醉时间、睁眼时间比较差异均无统计学意义（P〉0.05）。观察组患者躁动评分分布显著优于对照组（P〈0.05）。观察组患者T1~T4时MAP、HR均低于对照组（P〈0.05）;T1~T5时VAS评分均低于对照组（P〈0.05）。观察组和对照组患者不良反应发生率分别为35.0%和25.0%,2组患者不良反应发生率比较差异无统计学意义（P〉0.05）。结论术前给予帕瑞昔布钠对腹腔镜胆囊切除患者术后降低躁动、减轻疼痛、保持血流动力学的稳定性方面具有积极作用,同时不会增加术后不良反应的发生率。Objective To explore the effect of treatment of parecoxib sodium before laparoscopic cholecystectomy on the patients＇ dysphoria,pain and hemodynamic stability during recovery period. Methods A total of 80 cases of laparoscopic cholecystectomy by general anesthesia were divided into observation group and control group,with 40 cases in each group. Patients in the observation group were treated with intravenous injection of 40 mg parecoxib sodium 20 minutes before the surgery,meanwhile the patients in control group were given the same amount of saline before the surgery. The heart rate（ HR）,mean arterial pressure（ MAP）,visual analogue scale（ VAS）,restlessness score and adverse reactions in the two groups were compared. Results There was no significant difference in bleeding time,extubation time,anesthesia duration,and time consumed for the patients＇ returning into consciousness between the two groups（ P〉0. 05）. The restlessness score in the observation group was significantly better than that in control group（ P〈0. 05）. The MAP and HR at T1- T4 in observation group was lower than that in control group（ P〈0. 05）,while the VAS at T1- T5 in observation group was lower than that in control group（ P〈0. 05）. The incidence of adverse reaction in observation group and control group was 35. 0%,25. 0% respectively,there was no significant difference in the incidence of adverse reaction between the two groups（P 〉0. 05）. Conclusion The treatment of parecoxib sodium before laparoscopic cholecystectomy plays a positive role in reducing the patients＇ restlessness,relieving their pains and maintaining hemodynamic stability,meanwhile it produces no increase of the occurrence of postoperative adverse reactions.

关 键 词：帕瑞昔布钠 腹腔镜 胆囊切除术 躁动 疼痛 血流动力学 

分 类 号：R657.4[医药卫生—外科学]