柴芪汤对代谢综合征大鼠糖脂代谢及胰岛素抵抗的影响  

Effects of Chaiqi decoction on glucose and lipid metabolism and insulin resistance in rat model with metabolic syndrome

作　　者：王颖[1] 刘晶[1] 王新祥[1] 张立平[2] 

机构地区：[1]北京中医药大学东方医院,北京100078 [2]北京中医药大学国际交流与合作处

出　　处：《北京中医药大学学报》2015年第9期597-600,共4页Journal of Beijing University of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(No.81273695);教育部"211工程"重点学科建设项目(No.F001279_1)

摘　　要：目的观察不同剂量柴芪汤对代谢综合征模型大鼠糖脂代谢及胰岛素抵抗(IR)的影响。方法 56只大鼠分为正常组16只,模型组16只,柴芪汤低、中、高剂量组各8只。采用高脂高糖高盐饲料持续喂养方式复制大鼠代谢综合征模型。柴芪汤各组从第9周开始分别灌胃给予不同剂量:低剂量组为1.90 g/(kg·d),中剂量组5.71 g/(kg·d),高剂量组17.13 g/(kg·d)。实验第8周末,模型组与正常组随机选取8只大鼠采血,实验第12周末,各组大鼠均行腹主动脉采血。用生化法检测血脂(TG、TC、HDL-C、LDL-C)、空腹血糖(FBG),放免法检测空腹胰岛素(FINS),公式计算胰岛素抵抗指数(IRI)。结果治疗4周后,与模型组比较,柴芪汤低剂量组FINS、TG明显下降(P<0.05),HDL-C明显升高(P<0.05);高、中剂量组FINS、TG、TC、IRI明显下降(P<0.05),HDL-C明显升高(P<0.05)。结论柴芪汤可改善代谢综合征大鼠糖脂代谢,并能减轻IR,以中、高剂量效果明显。Objective To study the effects of Chaiqi decoction （ CQD） at different doses on glucose and lipid metabolism and insulin resistance（ IR） in metabolic syndrome （ MS） rat model.Methods The MS rat model was induced by feeding diet of high fat, high sugar and high salt.Altogether 56 male rats were randomly divided into normal group （ n =16 ） , model group （ n =16 ） , CQD low dose group （ low-dose group, n=8）, CQD middle dose group（mid-dose group, n=8） and CQD high dose group（high-dose group, n=8） .The low-, mid-, and high-groups were taken CQD by intragastric administration at dose of 1.90, 5.71 and 17.13 g/kg daily for four weeks.At the end of the 8th week, eight rats of normal group and model group were sacrificed, and at the end of the 12th week, all the rats in each group were sacrificed.Serum TG, TC, HDL-C, LDL-C, fasting blood glucose （ FBG） and fasting insulin （ FINS） were detected, while insulin resistance index （ IRI） was calculated.Results After taking CQD for four weeks , compared with model group, FINS and TG in low-dose group decreased significantly （P＜0.05） while HDL-C increased significantly （ P ＜0.05）; FINS, TG, TC, IRI decreased significantly while HDL-C increased significantly in both mid-and high-dose groups （P＜0.05）.Conclusion CQD would attenuate the lipid metabolism of rats with metabolic syndrome and reduce IR.Furthermore, the mid-dose＆amp;nbsp;group and high-dose group got better effects than those of low-dose group.

关 键 词：柴芪汤 代谢综合征 糖脂代谢 胰岛素抵抗 大鼠 

分 类 号：R285.5[医药卫生—中药学]