运动神经损伤在神经病理性疼痛中的作用及其机制  

The mechanisms underlying neuropathic pain produced by motor nerve injury

作　　者：刘先国[1] 徐婷[1] 

机构地区：[1]中山大学疼痛研究中心,广州510080

出　　处：《国际麻醉学与复苏杂志》2015年第10期922-924,共3页International Journal of Anesthesiology and Resuscitation

基　　金：国家自然科学基金-广东省联合基金重点项目（u1201223）

摘　　要：背景神经病理性疼痛（neuropathicpain，NP）严重影响患者的生活质量和工作能力。人们曾经认为感觉神经损伤引起NP，而最新研究表明，运动神经损伤在其中发挥更重要的作用。目的指出运动神经损伤在NP中的重要作用，以引起基础和临床研究者的关注。内容讨论NP相关的实验和临床证据。趋向回复运动功能或兴奋运动相关脑区可抑制NP。Background Neuropathic pain （NP） that damages patient＇s life and working ability is still a big challenge for pain clinician. It has been once believed that sensory nerve injury induces NP. However, recent works show that motor nerve injury may play more important role. Objective The role of motor nerve injury for generation of NP was emphasized to attract attention of basic and clinical pain researchers. Content In this article the related experimental and clinical evidences were reviewed and discussed. Trend Restoring motor function or stimulating motor-related brain areas may be attenuate NP.

关 键 词：运动神经损伤 神经病理性疼痛 致炎细胞因子 神经胶质细胞 

分 类 号：R688[医药卫生—骨科学]