24737例乙型肝炎HBsAg阳性者的病毒血清学模式回顾性分析  

Retrospectively analysis of serological patterns of hepatitis B virus in 24737 patients with positive HBsAg

作　　者：高卫亚 袁红萍[2] 杜忠祥 王璐[2] 邹丽敏[2] 王念跃[1,3] 

机构地区：[1]东南大学医学院,江苏南京210009 [2]丹阳市人民医院,江苏丹阳212300 [3]南京市第二人民医院,江苏南京210009

出　　处：《中国卫生检验杂志》2015年第19期3371-3374,共4页Chinese Journal of Health Laboratory Technology

摘　　要：目的统计分析乙型肝炎HBs Ag阳性者的血清学模式并探讨其临床意义,为进一步预防与控制乙型肝炎提供科学依据。方法回顾性分析2008年-2013年在南京市第二医院检测的24 737例HBs Ag阳性者的乙肝两对半模式。结果 24 737例HBs Ag阳性者共存在13种血清学阳性模式,主要为＂1、4、5＂和＂1、3、5＂阳性模式,分别占50.17%（12 410/24 737）和40.55%（10 030/24 737）。其他〉1%的阳性模式有4种,分别为＂1、3、4、5＂、＂1、5＂、＂1、2、3、5＂、＂1、2、4、5＂阳性模式,依次占2.87%、2.11%、1.77%、1.61%,其他7种低频模式检出率为0.01%~0.25%。＂1、3、5＂阳性模式在1岁~10岁、11岁~20岁、21岁~30岁3个年龄组占主要比例并随年龄增长所占比例逐渐降低,＂1、4、5＂阳性模式在31岁~40岁、41岁~50岁、51岁~60岁、61岁以上年龄组占主要比例并随年龄增长所占比例逐渐增高。结论年龄是影响HBe Ag/HBe Ab血清转换的因素,对40岁以上＂1、3、5＂阳性模式人群应积极治疗,并增加肝硬化及肝癌实验室相关指标监测。Objective To investigate the serological patterns of hepatitis B virus in HBs Ag- positive cases,so as to provide basis for the prevention and control of hepatitis B infection. Methods Retrospectively analyze all the serological patterns of hepatitis B virus in 24 737 patients with positive HBs A from 2008 to 2013 in the Second Hospital of Nanjing. Results 13 serological positive patterns were observed,and ＂1,4,5＂and ＂1,3,5＂positive patterns were the dominant patterns,respectively accounting for 50. 17%（ 12 410 /24 737） and 40. 55%（ 10 030 /24 737）,followed by＂1,3,4,5＂,＂1,5＂,＂1,2,3,5＂and＂1,2,4,5＂positive patterns,which were more than 1% and accounted for 2. 87%,2. 11%,1. 77%,and 1. 61%,and the rare rates for other 7 positive patters were 0. 01%- 0. 25%. The proportion of ＂1,3,5＂positive pattern was dominant in the 3 age groups of 1- 10,11- 20,21- 30,declining along with the growth of the age while the proportion of＂1,4,5＂positive pattern was dominant in the 4 age groups of 30- 40,41- 50,51- 60 and above 60,increasing along with the growth of the age. Conclusion Age is the factor of hepatitis B antigen seroconversion,we should treat the people who are＂1,3,5＂positive and add monitoring and test on liver cirrhosis and liver cancer.

关 键 词：乙型肝炎 乙型肝炎表面抗原 化学发光法 血清学模式 

分 类 号：R512.62[医药卫生—内科学]