Laminin-5,Cassis,Escin(LCE)修复霜促进点阵激光术后皮肤修复的研究  

Study on the acceleration of skin repair by LCE Balm in fractional laser treated skin

作　　者：郑跃[1] 陈海燕[1] 叶聪秀[1] 易金玲[1] 朱雯萱 谢小元[1] 赖维[1] 

机构地区：[1]中山大学附属第三医院皮肤科,广东广州510630

出　　处：《临床皮肤科杂志》2015年第11期688-691,共4页Journal of Clinical Dermatology

摘　　要：目的:研究Laminin-5,Cassis,Escin(LCE)修复霜对2 940 nm Er∶YAG点阵激光术后皮肤的修复作用。方法:试验采取随机双盲、半边脸自身对照的方法,2 940 nm Er:YAG点阵激光对15名受试者双侧眼角或眼周皱纹进行治疗。激光术后即刻及术后第1至第14天,试验侧使用A霜(LCE修复霜),阳性对照侧使用B霜(皮肤修护保湿霜),每日2次,共15 d。医生评估两种修复霜对点阵激光术后皮肤各种症状的改善作用,并检测皮肤血红素、含水量及经皮水分丢失(TEWL)值。结果:激光术后即刻使用两种修复霜,试验侧皮肤水肿评分为(4.7±0.3)分,明显低于阳性对照侧评分(6.9±0.5)分(P=0.036)。试验侧红斑持续时间为(4.0±0.3)d,短于阳性对照侧的(4.9±0.2)d(P=0.032),水肿持续时间(2.0±0.5)d短于阳性对照侧(4.0±0.7)d(P=0.041)。激光术后即刻、7 d及14 d,试验侧皮肤与阳性对照侧皮肤比较,两侧皮肤含水量、TEWL值及皮肤血红素值无统计学差异。结论:面部皮肤点阵激光术后使用LCE修复霜其功效与阳性对照产品基本相同。Objective： To evaluate the clinical efficacy of Laminin-5, Cassis, Escin（LCE Balm） in fractional laser treated skin. Methods： A total of 15 subjects were treated for eye wrinkles using 2940 nm Er：YAG fractional laser. Following laser treatment, a randomized, double-blind, split-face study was performed to evaluate the efficacy of LCE Balm（A cream） vs. Skin Recovery Cream （B cream）. One side of the face was treated with A cream while the other side was treated with B cream immediately after laser therapy, followed by twice daily for 14 days. Self-assessment questionnaire and the skin biophysical indices （hydration, TEWL and hemoglobin value） were used to evaluate the efficacy. Results： Immediately after the laser surgery treatment, the skin edema score was significantly lower in A cream-treated side than in B cream-treated side （4.7±0.3 vs. 6.9±0.5, P=0.036）. The duration of skin erythema in A cream-treated side was significantly shorter than that in B cream-treated side [（4.0±0.7） d vs. （4.9±0.2） d, P=0.032]. Moreover, the duration of skin edema in A creamtreated side was also significantly shorter than that in B cream-treated side [（2.0±0.5） d vs. （4.0±0.7） d, P=0.041]. However, the skin biophysical indices, including hydration, TEWL and hemoglobin were no significant differences between A cream and B cream treatments immediately, 7 days and 14 days after laser treatment. Conclusion： LCE Balm is safe and effective for skin repairing after fractional laser treatment, especially in alleviating the immediate postoperative skin edema and shortening the duration of postoperative inflammatory erythema.

关 键 词：层粘连蛋白-5短肽 皮肤修复 点阵激光 

分 类 号：R751.05[医药卫生—皮肤病学与性病学]