表皮葡萄球菌对莫匹罗星的耐药性研究  

Study on the resistance of Staphylococcus epidermidis to mupirocin

作　　者：林纯婵 陈舒影 丁宇[1] 李丹[1] 张雪青[1] 王良兴[2] 余方友[1] 

机构地区：[1]温州医科大学附属第一医院检验科,浙江温州325000 [2]温州医科大学附属第一医院呼吸科,浙江温州325000

出　　处：《中国临床药理学杂志》2015年第20期2021-2023,共3页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金资助项目(81472011H2002)

摘　　要：目的了解表皮葡萄球菌对莫匹罗星的耐药情况,并探讨其耐药菌株对临床常用抗菌药物的耐药特性。方法收集2012年到2014年分离的表皮葡萄球菌498株,对表皮葡萄球菌临床分离株进行菌种鉴定和药敏试验;用K-B法测定表皮葡萄球菌临床分离株对莫匹罗星的耐药性。结果 498株表皮葡萄球菌中,39株对莫匹罗星耐药,耐药率为7.8%(39/498)。39株莫匹罗星耐药的表皮葡萄球菌均为耐甲氧西林表皮葡萄球菌(MRSE)。39株耐莫匹罗星的MRSE对奎诺普丁/达福普汀、利奈唑胺、万古霉素和呋喃妥因均表现为敏感,对青霉素、克林霉素、红霉素、环丙沙星和磺胺甲唑/甲氧苄啶等耐药率较高(>60%),对庆大霉素、利福平耐药率超过35%。结论莫匹罗星对表皮葡萄球菌表现出较好的体外抗菌活性,但对莫匹罗星耐药的表皮葡萄球菌已在临床分离株中出现,耐药性问题不容忽视。Objective To investigate the resistance of Staphylococcus epidermidis isolates to mupiroein and its resistant characteristics to anti- bacterial agents used in clinical. Methods A total of 489 Staphyloco- ccus epidermidis isoliates were isolated from the various specimens of pa- tients in our Hospital. The identification and antimicrobial susceptibility testing of Staphylococcus epidermidis isolates were determined by Vitek - 2 Compact full automated Microbiology Analyzer. The susceptibility of 489 Staphylococcus epiderrnidis isolates to mupirocin was determined by disc - diffusion method. Results Among 489 Staphylococcus epidermidis clini- cal isolates, 39 methicillin - resistant Staphylococcus epidermidis （MRSE） were resistant to mupirocin. The prevalence of mupirocin resis- tance among Staphylococcus epidermidis clinical isolates was 7. 8% （39/498）. All mupirocin -resistant isolates were susceptible to quinu- pristin/dalfopristin, linezolid, vancomycin and nitrofurantoin. While more than 60% of mupirocin - resistant isolates were resistant to penici- llin, clindamycin, erythromycin and trimethoprim/sulfamethoxazole. The resistance rates of mupirocin -resistant isolates to gentamicin and rifapin were more than 35%. Conclusion Mupirocin is an effective agent against Staphylococcus epidermidis isolates in vitro. However, the mupiro- cin- resistant Staphylococcus epidermidis has appeared in clinical isolates which is of concern.

关 键 词：表皮葡萄球菌 莫匹罗星 耐药率 

分 类 号：R978.1[医药卫生—药品] R979.3[医药卫生—药学]