青年冠心病患者血清胆红素水平与血脂水平及冠脉病变程度关系的临床观察  

Clinical Investigation on relationship between serum bilirubin level and lipid level and coronary artery severity in young patients

作　　者：杨海涛[1] 王山岭[1] 钱鹏[1] 吴金涛[1] 严丽洁[1] 范宪伟[1] 

机构地区：[1]河南省人民医院心内科,郑州450003

出　　处：《医药论坛杂志》2015年第10期27-29,共3页Journal of Medical Forum

摘　　要：目的探究青年冠心病患者血清胆红素水平与血脂水平及冠脉病变程度的相关性,就血清胆红素水平与青年冠心病的关系做初步探讨。方法选取河南省人民医院经冠脉造影证实的青年冠心病患者48例为观察组,分别将青年冠心病患者的胆红素的各成份与血脂进行Pearson直线相关分析,与冠脉病变积分为作Spearman直线相关分析。结果结果显示青年冠心病患者的总胆红素、间接胆红素水平均与高密度脂蛋白呈显著正相关,相关系数r=0.305和0.315,均与低密度脂蛋白呈显著负相关,相关系数r=-0.235和-0.264,直接胆红素水平与低密度脂蛋白呈显著负相关,相关系数r=-0.203,以上P均<0.05;血清总胆红素水平与冠脉病变积分之间存在负相关关系,相关系数-0.288,P<0.05。结论青年冠心病患者血清胆红素水平与血脂之间存在相关性,其中总胆红素水平与高密度脂蛋白呈显著正相关,与低密度脂蛋白呈显著负相关;青年冠心病患者血清总胆红素水平与冠脉病变积分之间存在负相关性。Objective To investigate the relationship between serum bilirubin level and lipid level and coronary artery severity in young patients. Methods Blood samples form all 48 consecutive young CHD patients were used to carry on correlation analysis between bilirubin level and lipid level,bilirubin level and coronary severity scores. Results Pearson correlation analysis showed that the level of TBIL was directly correlated with HDL- C（ r = 0. 305,P〈0. 05）,inversely correlated with LDL- C（ r =- 0. 235,P〈0. 05）,The level of IBIL was directly correlated with HDL- C（ r =0. 315,P〈0. 05）,and inversely correlated with LDL- C（ r =- 0. 264,P〈0. 05）,The level of DBIL was inversely correlated with LDL- C（ r =- 0. 203,P〈0. 05）; Spearman correlation analysis showed that the level of TBIL was inversely correlated with coronary severity scores（ r =- 0. 288,P〈0. 05）. Conclusion There was correlation between the level of serum bilirubin and lipid,and the level of serum total bilirubin was directly correlated with HDL- C,inversely correlated with LDL- C in the young CHD group; The level of serum total bilirubin was inversely correlated with coronary severity scores in the young CHD group.

关 键 词：血清胆红素 青年冠心病 血脂 冠脉病变程度 

分 类 号：R541.4[医药卫生—心血管疾病]