针刺治疗围绝经期综合征疗效系统评价  

Systematic Evaluation of the Efficacy of Acupuncture on Perimenopausal Syndrome

作　　者：曹徵良 王琼[1] 李赛群[1] 孙佳琪[1] 周有君 章薇[2] 

机构地区：[1]湖南中医药大学,湖南长沙410007 [2]湖南中医药大学第一附属医院,湖南长沙410000

出　　处：《针灸临床杂志》2015年第9期60-64,共5页Journal of Clinical Acupuncture and Moxibustion

基　　金：国家十二五科技支撑计划项目;编号:2012BAI24B01

摘　　要：目的:评价国内针刺治疗围绝经期综合征的临床疗效。方法:以针刺、针灸、电针、体针、耳针、头针、梅花针、激光针、水针、耳穴压豆等和围绝经期、围绝经期综合征、更年期、更年期综合征等词组作为检索词,分别检索了2010年至今的CNKI、VIP、万方等数据库中获得发表的针刺治疗围绝经期综合征的临床随机或半随机对照试验文献。两名评价者独立提取资料、评价研究文献质量及结局,用Meta分析方法对资料进行评价。结果:共纳入随机对照文献28篇。Meta分析结果显示:疗效分析总有效率:各组在各结局指标上均无异质性(P=0.53,I2=0%),与对照组相比,针灸组提高总疗效3.15倍,其差异有统计学意义[OR=3.51,95%CI(2.50,4.95),P<0.0001];MI指数:各组在各结局指标上均无异质性(P=0.19,I2=33%),与对照组相比,针灸组提高总疗效5.04倍,其差异有统计学意义[MD=5.04,95%CI(3.72,6.36),P<0.0001]。发表偏倚分析结果提示无明显发表偏倚。敏感性分析结果稳定性好。结论:近年来针刺治疗围绝经期综合征疗效显著,但国内大部分研究文献的质量较低,应建立多中心临床随机对照试验,注重提高针灸治疗围绝经期综合征的方法学质量,目前尚需更多高质量的随机对照研究证实针刺治疗围绝经期综合征的疗效。Objective： To evaluate the clinical effect of acupuncture on perimenopausal syndrome. Methods：Needling,acupuncture,electroacupuncture,body acupuncture,ear acupuncture,scalp acupuncture,plum blossom needling,water needling,laser needling,ear pressure beans menopausal,menopausal syndrome,menopause were searched as key words,since 2010,CNKI,VIP,Wan Fang data of clinical randomized or quasi randomized controlled trials published in the library of acupuncture treatment for perimenopausal syndrome. Two reviewers independently extracted the data,evaluation of quality and outcomes of research literature,the evaluation method of data analysis by Meta. Results： A total of 28 literatures were included. Meta analysis results showed that： the total effective rate： analysis of curative effect of each group had no heterogeneity in the outcome indicators（ P = 0. 53,I2= 0%）. Compared with the control group,the total effect of acupuncture group increased 3. 15 times,and the difference was statistically significant（ OR = 3. 51,95% CI,P 〈0. 0001）（ 2. 50,4. 95）. The MI index： each group had no heterogeneity in the outcome indicators（ P = 0. 19,I^2= 33%）. Compared with the control group,the total effect of acupuncture group increased 5. 04 times,and the difference was statistically significant（ MD = 5. 04,95% CI,P〈 0. 0001）（ 3. 72,6. 36）. Publication bias analysis showed that：there was no significant publication bias. Conclusion： Acupuncture for the treatment of perimenopausal syndrome is distinct,but the quality of most of the domestic researches is relatively low,and it should establish a multi center randomized controlled clinical trial,focusing on improving the quality of acupuncture in the treatment of perimenopausal syndrome. At present,we still need more high quality randomized controlled studies to confirm the efficacy of acupuncture on perimenopausal syndrome.

关 键 词：针刺 围绝经期综合征 更年期 系统评价 

分 类 号：R246.3[医药卫生—针灸推拿学]