超声造影对中毒兔肝脏微循环的实验研究  

Experimental research of contrast-enhanced ultrasound on microcirculation of rabbit liver with organophosphorus poisoning using

作　　者：钱嵘[1] 熊爱民[1] 杨唯衷 王秀梅[1] 刘文杰[1] 刘萍[1] 徐振[1] 王丹妮[1] 柯晶晶[1] 吕瑞[1] 陈婷婷[1] 李晶[1] 杨峻[2] 

机构地区：[1]解放军第八五医院特诊科,上海200052 [2]解放军第八五医院检验科,上海200052

出　　处：《肝脏》2015年第7期526-528,共3页Chinese Hepatology

基　　金：南京军区重点课题(11Z001)

摘　　要：目的探讨超声造影评价有机磷中毒兔肝损害的价值。方法新西兰大白兔40只,腹腔注射有机磷染毒,分别于染毒前及染毒后2、4、6、8、10 h行常规超声及超声造影检查,测定肝右叶前后径、造影剂肝动脉到达时间(HAAT)、肝静脉到达时间(HVAT)及肝动-静脉渡越时间(HA-HVTT)等指标。结果染毒前后各时间段肝右叶前后径测值无明显改变(P>0.05),染毒后6小时、8小时、10小时肝静脉到达时间较前缩短,分别为7.23±2.63、6.38±2.49、6.25±2.84(P<0.05),染毒后8小时,10小时肝动静脉渡越时间明显缩短,分别为2.38±1.02、1.51±0.92(P<0.05)。结论HVAT及HA-VTT可以反映有机磷中毒兔肝脏微循环的变化。Objective To investigate the value of contrast-enhanced ultrasound in assessment of the liver poisoning damages caused by organophosphorus.Methods Animal models of organophosphorus poisoning were established by intraperitoneal injection in 40 rabbits.Conventional ultrasound and contrast-enhanced ultrasound were carried out to measure several evaluation indexes respectively,including anteroposterior diameter of right liver lobe,hepatic artery arrival time（HAAT）,hepatic vein arrival time（HVAT）and hepatic artery to hepatic vein transit time（HA-HVTT）,before and2 h,4h,6h,8h and 10 h after injection.Results Compared with the pre-poisoning data,anteroposterior diameter of right liver lobe had no obvious change after organophosphorus poisoning（P0.05）.Meanwhile,HVAT at 6h,8h and 10 h postpoisoning was decreased（P0.05）.HA-HVTT significantly declined at 8h and 10 h post-poisoning（P0.05）.Conclusion HVAT and HA-HVTT can indicate the changes of the liver microcirculation in rabbit suffering organophosphorus poisoning.

关 键 词：超声造影 有机磷中毒 肝脏 兔 

分 类 号：R445.1[医药卫生—影像医学与核医学] R595.4[医药卫生—诊断学]