TAPP1 inhibits the differentiation of oligodendrocyte precursor cells via suppressing the Mek/Erk pathway  

作　　者：Yidan Chen Ruyi Mei Peng Teng Aifen Yang Xuemei Hu Zunyi Zhang Mengsheng Qiu Xiaofeng Zhao 

机构地区：[1]Institute of Developmental and Regenerative Biology, Zhejiang Key Laboratory of Organ Development and Regeneration,College of Life and Environmental Sciences, Hangzhou Normal University [2]Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville

出　　处：《Neuroscience Bulletin》2015年第5期517-526,共10页神经科学通报（英文版）

基　　金：supported by the National Natural Sciences Foundation of China (31471955 and 31372150);the National Basic Research Development Program (973 Program) of China (2013CB531300)

摘　　要：Oligodendrocytes（OLs） are glial cells that form myelin sheaths around axons in the central nervous system（CNS）.Loss of the myelin sheath in demyelinating and neurodegenerative diseases can lead to severe impairment of movement.Understanding the extracellular signals and intracellular factors that regulate OL differentiation and myelination during development can help to develop novel strategies for enhancing myelin repair in neurological disorders.Here,we report that TAPP1 was selectively expressed in differentiating OL precursor cells（OPCs）.TAPP1 knockdown promoted OL differentiation and myelin gene expression in culture.Conversely,over-expression of TAPP1 in immature OPCs suppressed their differentiation.Moreover,TAPP1 inhibition in OPCs altered the expression of Erk1/2 but not AKT.Taken together,our results identify TAPP1 as an important negative regulator of OPC differentiation through the Mek/Erk signaling pathway.Oligodendrocytes（OLs） are glial cells that form myelin sheaths around axons in the central nervous system（CNS）.Loss of the myelin sheath in demyelinating and neurodegenerative diseases can lead to severe impairment of movement.Understanding the extracellular signals and intracellular factors that regulate OL differentiation and myelination during development can help to develop novel strategies for enhancing myelin repair in neurological disorders.Here,we report that TAPP1 was selectively expressed in differentiating OL precursor cells（OPCs）.TAPP1 knockdown promoted OL differentiation and myelin gene expression in culture.Conversely,over-expression of TAPP1 in immature OPCs suppressed their differentiation.Moreover,TAPP1 inhibition in OPCs altered the expression of Erk1/2 but not AKT.Taken together,our results identify TAPP1 as an important negative regulator of OPC differentiation through the Mek/Erk signaling pathway.

关 键 词：TAPP1 differentiation oligodendrocyte spinal cord 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]