白芍总苷联合中药辨证治疗老年慢性原发免疫性血小板减少症的临床观察  

Clinic Research of Total Glucosides of Peony Therapy Combined with Chinese Medicine Syndrome Differentiation on Elderly Patients with Chronic Idiopathic Thrombocytopenic Purpura

作　　者：吴玉霞[1] 袁忠[1] 白玉盛[1] 黄志惠[1] 费飞[1] 

机构地区：[1]新疆医科大学附属中医医院,乌鲁木齐830000

出　　处：《世界中医药》2015年第9期1340-1343,共4页World Chinese Medicine

基　　金：新疆维吾尔自治区自然科学基金项目--中药治疗慢性免疫性血小板减少症疗效机制的研究(编号:201233146-18)

摘　　要：目的:观察白芍总苷联合中药辨证治疗老年慢性原发免疫性血小板减少症的疗效。方法:63例老年原发免疫性血小板减少症患者随机分为对照组(30例)及治疗组(33例),对照组应用基础常规治疗及中药辨证施治,治疗组在对照组基础上联合白芍总苷胶囊600 mg,3次/d,口服,疗程均为3个月,观察2组患者临床疗效,治疗前后血小板、出血症状改善及起效时间比较。结果:1)治疗组总有效率81.81%,对照组总有效率60.00%。2组间比较均有统计学意义(P<0.05);2)治疗组在提高血小板水平、改善出血症状及起效时间方面均优于对照组(P<0.05);3)治疗组中3个不同证型患者疗效比较,气虚失摄型、血热妄行型优于阴虚火旺型(P<0.05);4)有8例患者在治疗起始阶段出现腹泻症状,经对症处理后腹泻即止。肝功能、肾功能,电解质等生化指标与心电图及胸部X线片在患者治疗后复查均无异常,无加重甚至减轻原有并发症。结论:白芍总苷联合中辨证治疗老年慢性原发免疫性血小板减少症提高外周血小板水平,起效时间短,改善出血症状,不良反应小,尤适用于气血不摄型、血热妄行型,具有较好的治疗效果。Objective：To observe the effect of Total Glucosides of Peony（TGP） combined with Chinese medicine on elderly patients with Chronic Idiopathic Thrombocytopenic Purpura（CITP）.Methods：Old patients with CITP of 63 cases were randomly divided into two groups：control group（33 cases）,treatment group（33 cases）.The control group was given traditional treatment combined with Chinese medicine syndrome differentiation while the treatment group was given oral TGP（600 mg per time,3 times per day） adding to the treatment of the control group.The therapeutic course was 3 months for the two groups.The platelet count level,the bleeding sites were observed before and after treatment as well as the clinical efficacy.Results：Firstly,the total effective rate of treatment group was 81.81%and 60.00%of control group,showing significant difference（P 0.05）.Secondly,the platelet level,bleeding site,and effective time of the treatment group were all better than those of the control group with significant diffidence（P 0.05）.Thirdly,the total effective rate showed significant diffierence within three syndromes in the treatment group（P 0.05）,syndrome of qi failing to control blood and renetic stirring of blood heat had better improvement than syndrome of yin deficiency and effulgent fire.Fourthly,there were eight patients having symptoms of diarrhea at the beginning of the treatment but recovered after treatment.Related indexes in western medicine showed no abnormalities.Original complications didn＇t aggravate but even recovered.Conclusion：TGP combined with Chinese medicine can improve the level of peripheral blood platelet,shorten the onset time and effectively control bleeding symptoms with little adverse effect,especially for the syndrome of qi failing to control blood and renetic stirring of blood heat.

关 键 词：老年慢性原发性免疫性血小板减少症 白芍总苷胶囊 中医辨证治疗 

分 类 号：R259[医药卫生—中西医结合]