尿毒清颗粒辅助治疗糖尿病肾病系统评价  

Systematic Review on Assisted Treatment for Diabetic Nephropathy with Niaoduqing Granule

作　　者：栾伟[1] 尹红[1] 古今[1] 

机构地区：[1]解放军总医院药品保障中心,北京100853

出　　处：《辽宁中医药大学学报》2015年第10期131-135,共5页Journal of Liaoning University of Traditional Chinese Medicine

摘　　要：目的:系统评价尿毒清颗粒辅助治疗糖尿病肾病(DN)的疗效及安全性。方法:计算机检索Cochrane图书馆临床对照试验数据库、维普中文生物医学期刊数据库(CMJD)、中国期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、MEDLINE、EMbase中尿毒清颗粒辅助治疗糖尿病肾病的随机对照试验,由两名研究者独立进行资料提取和质量评价后,采用Rev Man5.3软件进行Meta分析。结果:共纳入15个随机对照研究,共1081例患者。Meta分析结果显示:尿毒清颗粒辅助治疗糖尿病肾病患者可以提高Ccr,减少UAER、24 h UTP,降低Scr、BUN水平;对降低空腹血糖无效;无严重不良反应。结论:尿毒清颗粒辅助治疗糖尿病肾病具有一定疗效,但由于纳入研究质量偏低,样本量小,可能存在发表偏倚、语种偏倚及其他偏倚,因此需要更高质量的研究对其疗效及安全性进行证实。Objective：To systematically evaluate the efficacy and safety of assisted treatment for diabetic nephropathy（DN）with Niaoduqing Granule. Methods：The Cochrane Library,CNKI,CBM,MEDLINE and EMbase were retrieved by computer for collecting the randomized controlled trials（RCTs）of assisted treatment for diabetic nephropathy with Niaoduqing Granule,two researchers collected data and evaluated quality independently,and then the data was analyzed by Rev Man5.3 software. Results：15 RCTs involving 1081 patients were ultimately identified. The results of meta-analysis showed that Niaoduqing Granule was better for treating diabetic nephropathy including of increasing Ccr,reducing UAER and 24 h UTP,and decreasing Scr and BUN,besides no serious adverse reaction,but there was no effect on decreasing the fasting blood glucose. Conclusion：There was a certain of effect on treating diabetic nephropathy with Niaoduqing Granule,but the publication bias,language bias and other bias may also existed because of low methodological quality and small sample size. More high quality trials are required to confirm the efficacy and safety.

关 键 词：尿毒清颗粒 糖尿病肾病 系统评价 META分析 

分 类 号：R587.2[医药卫生—内分泌]