冠心病患者血清同型半胱氨酸对血脂和锰超氧化物歧化酶的影响  

Effects of Homocysteine on Blood Lipid and Manganese Superoxide Dismutase in Patients with Coronary Heart Disease

作　　者：赵佳[1] 姚创利[1] 左林[4] 黎阳[1] 姜小建[1] 杨军乐[2] 辛渭川[3] 

机构地区：[1]西安市中心医院检验科,西安710003 [2]西安市中心医院放射科,西安710003 [3]西安市中心医院心内科,西安710003 [4]第四军医大学唐都医院放射科,西安710038

出　　处：《现代检验医学杂志》2015年第5期44-45,49,共3页Journal of Modern Laboratory Medicine

基　　金：陕西省科学技术研究发展计划项目（项目编号：2013K12-02-10）.

摘　　要：目的 探讨冠心病患者血清同型半胱氨酸（Hcy）水平与血脂水平和锰超氧化物歧化酶（Mn-SOD）活性的关系.方法 选取2014年3月～10月期间入住西安市中心医院的82例冠心病患者作为研究对象,应用酶法测定血清Hcy水平,应用终点法测定血清胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）水平,应用免疫比浊法测定血清载脂蛋白AⅠ （ApoAⅠ）和载脂蛋白B（ApoB）水平,应用比色法测定血清Mn-SOD活性,将Hcy水平与血脂水平和Mn-SOD活性进行Pearson相关分析.结果 冠心病组血清Hcy水平高于对照组,差异具有统计学意义（t=3.65,P＜0.05）.冠心病组血清Hcy水平与TC,TG,HDL-C和LDL-C水平无明显相关性;冠心病组血清Hcy水平与ApoA Ⅰ和ApoB水平呈负相关（r=-0.276,P＜0.05;r=-0.239,P＜0.05）.冠心病组血清Hcy水平与Mn-SOD活性呈负相关（r=-0.218,P＜0.05）.结论 高Hcy是冠心病的危险因素之一.高Hcy可能通过影响ApoA Ⅰ和ApoB参与脂质的代谢和动脉粥样硬化的形成,进而促进冠心病的发生发展.高Hcy可能通过抑制Mn-SOD的活性而削弱机体抗氧化的能力,造成血管内皮细胞过氧化损伤.Objective To investigate the relationship between homocysteine level and blood lipid and manganese superoxide dismutase level in patients with coronary heart disease. Methods 82 patients with coronary heart disease in Xi＇ an Central Hospital from March to October 2014 were selected as research subjects. Homocysteine （Hcy） level was detected by enzy- matic method, cholesterol （TC）, triglyceride （TG）, high density lipoprotein cholesterol （HDL-C） and low density lipoprotein cholesterol （LDL-C） levels were detected by end-point method, apolipoprotein AI （ApoA I） and apolipoprotein B （ApoB） levels were detected by immune turbidimetric method. Colorimeter was used to detect the serum manganese superoxide dis- mutase （Mn-SOD） activity. The results were analyzed using Pearson correlation analysis. Results Compared with the con- trol group,the serum Hcy level in the coronary heart disease group was significantly higher, the difference was statistically significant （t=3.65, P〈0.05）. In the coronary heart disease group, there was no significant correlation between the serum Hcy level and TC,TG, HDL-C and LDL-C levels;the serum Hcy level and ApoA I and ApoB levels showed a negative correlation （r=- 0. 276, P〈0. 05;r=-0. 239, P〈0.05）. In the coronary heart disease group, the serum Hcy level and Mn-SOD level showed a negative correlation （r=-0. 218,P〈0.05）. Conclusion Hyperhomocysteinemia is a risk factor for coronary heart disease. Hyperhomocysteinemia may be involved in lipid metabolism and atherosclerosis formation by influencing ApoA and ApoB. Hyperhomocysteinemia may inhibit Mn-SOD activity and weaken antioxidant ability, resulting in endothelial cell peroxidation injury.

关 键 词：同型半胱氨酸 冠心病 血脂 锰超氧化物歧化酶 

分 类 号：R541.4[医药卫生—心血管疾病] R446.112[医药卫生—内科学]