Efficient synthesis of 2-arylquinazolines via copper-catalyzed dual oxidative benzylic C–H aminations of methylarenes  

作　　者：Li-Yan Liu Yi-Zhe Yan Ya-Jie Bao Zhi-Yong Wang 

机构地区：[1]Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Soft Matter Chemistry & Collaborative Innovation Center of Suzhou Nano Science and Technology, University of Science and Technology of China

出　　处：《Chinese Chemical Letters》2015年第10期1216-1220,共5页中国化学快报（英文版）

基　　金：the National Nature Science Foundation of China (Nos. 2127222, 91213303, 21172205, 21432009, 21472177)

摘　　要：A novel copper-catalyzed dual oxidative benzylic C–H aminations of methylarenes with 2-aminobenzoketones in the presence of ammonium acetate was developed. This reaction represents a new avenue for 2-arylquinazolines with good yields. A key intermediate was detected and the kinetics isotope effect（KIE） indicated that C–H bond cleavage was the rate-determining step.A novel copper-catalyzed dual oxidative benzylic C–H aminations of methylarenes with 2-aminobenzoketones in the presence of ammonium acetate was developed. This reaction represents a new avenue for 2-arylquinazolines with good yields. A key intermediate was detected and the kinetics isotope effect（KIE） indicated that C–H bond cleavage was the rate-determining step.

关 键 词：Quinazolines Copper C–H aminations Methylarenes 

分 类 号：O621.3[理学—有机化学]