Facile synthesis of 1-naphthols through a copper-catalyzed arylation of methyl ketones with o-bromoacetophenones  

作　　者：Zhen-Bang Lou Xin-Long Pang Chao Chen Li-Rong Wen Ming Li 

机构地区：[1]College of Chemistry and Molecular Engineering Qingdao University of Science and Technology [2]Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology(Ministry of Education), Department of Chemistry, Tsinghua University

出　　处：《Chinese Chemical Letters》2015年第10期1231-1235,共5页中国化学快报（英文版）

基　　金：supported by National Natural Science Foundation of China (Nos. 21102080, 21372138);Tsinghua University Initiative Scientific Research Program (No. 2011Z02150)

摘　　要：The coupling reactions of simple methyl ketones with o-bromoacetophenones and subsquential cyclization reactions were realized to produce a range of 1-naphthols. These cascade reactions were initiated by a rare Cu-catalyzed arylation reaction of methyl ketones with aromatic bromides.The coupling reactions of simple methyl ketones with o-bromoacetophenones and subsquential cyclization reactions were realized to produce a range of 1-naphthols. These cascade reactions were initiated by a rare Cu-catalyzed arylation reaction of methyl ketones with aromatic bromides.

关 键 词：Copper Arylation Ketones Naphthol 

分 类 号：O621.251[理学—有机化学]