Metal-free one-pot synthesis of quinoline-2,4-carboxylates via a molecular iodine-catalyzed three-component reaction of arylamines, ethyl glyoxylate, and α-ketoesters  

作　　者：Guang-Ming Nan Wei Liu 

机构地区：[1]College of Chemistry and Biology, Xinjiang Laboratory of Phase Transitions and Microstructures of Condensed Matters, Yili Normal University

出　　处：《Chinese Chemical Letters》2015年第10期1289-1292,共4页中国化学快报（英文版）

基　　金：supported by the Opening Project of Key Laboratory at Universities of Education Department of Xinjiang Uygur Autonomous Region (No. 2014YSHXZD01)

摘　　要：A simple and metal-free method has been developed for the construction of quinoline-2,4-carboxylates under mild conditions via a molecular iodine-catalyzed three-component tandem reaction of arylamines, ethyl glyoxylate, and a-ketoesters. The present protocol provides a convenient and attractive approach to various quinoline-2,4-carboxylates in moderate to good yields with excellent functional group tolerance.A simple and metal-free method has been developed for the construction of quinoline-2,4-carboxylates under mild conditions via a molecular iodine-catalyzed three-component tandem reaction of arylamines, ethyl glyoxylate, and a-ketoesters. The present protocol provides a convenient and attractive approach to various quinoline-2,4-carboxylates in moderate to good yields with excellent functional group tolerance.

关 键 词：Molecular iodine Quinoline-2 4-carboxylates Three-component Tandem reaction 

分 类 号：O626.323[理学—有机化学]