肝细胞肝癌多层螺旋CT征象与肿瘤血管生成相关性的研究  

A Study of the Correlation between the Features of Multislice Computed Tomography and Angiogenesis in Hepatocellular Carcinomas

作　　者：熊义富[1,2] 张小明[1] 杨林[1] 闵旭立 彭娟[1] 杨科[1] 

机构地区：[1]川北医学院附属医院放射科医学影像四川省重点实验室,四川南充637000 [2]湖北省宜昌市夷陵医院放射科,湖北宜昌443100

出　　处：《中国CT和MRI杂志》2015年第11期50-53,共4页Chinese Journal of CT and MRI

基　　金：四川省科技厅项目(2008JY0088-2);四川省教育厅重点项目(07ZA030)

摘　　要：目的探讨肝细胞肝癌(Hepatocellular carcinoma,HCC)的多层螺旋CT(Multislice computed tomography,MSCT)征象与肿瘤血管生成的相关性。方法运用免疫组织化学Elivison法检测41例HCC组织缺氧诱导因子-1α(Hypoxia-inducible factor-1α,HIF-1α)、血管内皮生长因子(Vascular endothelial growth factor,VEGF)的表达及微血管密度(Microvessel density,MVD)。所有病例术前均行MSCT平扫及增强扫描。结果 HIF-1α、VEGF表达及MVD值在瘤体直径≤5cm组和>5cm组的差异均无统计学意义(P>0.05);在边缘假包膜欠完整或无假包膜组和假包膜完整组、侵袭转移高危组和侵袭转移低危组、以及动脉供血和双重供血组的差异均有统计学意义(P<0.05)。结论 HCC的MSCT征象与HIF-1α、VEGF表达及MVD值密切相关;MSCT征象可以反映HCC病理及生物学特性。Objective To explore the correlation between multislice computed tomography（MSCT） features and angiogenesis in hepatocellular carcinoma（HCC）. Methods Fortyone cases of surgically excised HCC tissue samples that were pathologically diagnosed were analyzed by Elivisonimmunohistochemistry to detect the expression of hypoxiainducible factor-1α（HIF-1α） and vascular endothelial growth factor（VEGF） and assess microvessel density（MVD）. All of the patients were preoperatively examined with plain and enhanced CT. Results The differences of positive expression rates of HIF-1α and VEGF and the MVD values in HCC with a tumor diameter ≤ 5cm and 5 cm were not statistically significant（P〈0.05）. The positive expression rates of HIF-1α and VEGF and the MVD values in tumors with ruptured pseudocapsules or without pseudocapsules, a high risk of metastasis and invasion, and arterial blood were higher than those in tumors with intact capsules, a low risk of metastasis and invasion, and double blood supply, the group differences were statistically significant（P〈0.05）. Conclusion Conclusion MSCT manifestations of HCC with HIF-1 alpha, closely related to the expression of VEGF and MVD value; MSCT signs can reflect HCC pathological and biological characteristics.

关 键 词：肝细胞癌 多层螺旋CT 微血管密度 缺氧诱导因子-1Α 

分 类 号：R814.42[医药卫生—影像医学与核医学] R735.7[医药卫生—放射医学]