NAG,Cys C和mALB检测对妊娠高血压综合征早期肾损害的诊断意义  

Significance of NAG,CysC and mALB for early renal damage of pregnancy-induced hypertension

作　　者：李峻[1] 马琼燕 

机构地区：[1]上海市浦东新区公利医院,上海200135

出　　处：《现代中西医结合杂志》2015年第32期3559-3561,共3页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的探讨尿N-乙酰-B-D-氨基葡萄糖苷酶(NAG)、血清胱抑素C(Cys C)、尿微量白蛋白(m ALB)检测在妊娠高血压综合征(妊高征)早期肾损害诊断中的临床意义。方法选取妊高征患者80例作为妊高征组,其中妊娠高血压20例,子痫前期轻度34例和子痫前期重度26例,按照内生肌酐清除率(Ccr)水平将80例妊高征患者分为肾功能异常组(Ccr<80 m L/min)42例和肾功能正常组(Ccr≥80 m L/min)38例。另选择同期孕产期健康体检的孕妇30例作为正常妊娠组。检测2组尿NAG、m ALB和血清Cys C水平,分析妊高征患者尿NAG、m ALB和血清Cys C水平变化与疾病严重程度和是否合并肾功能损害的关系。结果妊高征组尿NAG、m ALB和血清Cys C水平均明显高于正常妊娠组(P均<0.05)。随着妊娠高血压程度的加重,尿NAG、m ALB和血清Cys C水平也逐渐升高(P均<0.05);肾功能正常组尿NAG、m ALB和血清Cys C水平均明显低于肾功能异常组(P均<0.05)。结论在妊高征患者中,尿NAG、m ALB和血清Cys C水平随着病情的加重而升高,三者联合检测有助于早期发现妊高征合并肾功能损害。Objective It is to observe the significance of N- acetyl- 13- D- glucosaminidase （NAG）, cystatin （CysC） and microalbuminuria （mALB） for early renal damage of pregnancy-induced hypertension. Methods 80 patients with pregnan- cy-induced hypertension were observed as pregnancy-induced hypertension group, in which there were 20 cases of pregnancy- induced hypertension, 34 cases of mild preeclampsia and 26 cases of severe preeclampsia, and according to serum crcatinine （Ccr） they were divided into renal dysfunction group （42 cases） （Ccr 〈 80 mL/min） and normal renal function group （38 cases） （Ccr≥80 mL/min）. 30 normal pregnant women at the same period were selected as normal pregnancy group. The levels of NAG, Cys C and mALB were observed in the two groups, the relation among the levels of those, severity of the disease and renal dysfunction were analyzed. Results The levels of NAG, Cys C and mALB is significantly higher than those in normal pregnancy group （P 〈 0.01 ）. The levels of NAG, Cys C and mALB in pregnancy-induced hypertension group increased as the severity of hypertension gradually increased （ P 〈 0.01 ）. The levels of NAG, Cys C and mALB in normal renal function group were significantly lower compared with the renal dysfunction group （P 〈0.01 ）. Conclusion The serum levels of NAG, Cys C and mALB in pregnancy-induced hypertension increase as the severity of disease rises, combined detection maybe help to early detect renal impairment in patients with pregnancy-induced hypertension.

关 键 词：N-乙酰-B-D-氨基葡萄糖苷酶 胱抑素C 尿微量白蛋白 妊娠高血压综合征 肾功能损害 

分 类 号：R714.246[医药卫生—妇产科学]