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作 者:郝光[1] 沈启明[1] 王馨[1] 马丽红[1] 王增武[1]
机构地区:[1]国家心血管病中心,中国医学科学院北京协和医学院阜外心血管病医院社区防治部,100037
出 处:《心脑血管病防治》2015年第5期369-371,共3页CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT
摘 要:目的探讨丹红注射液对兔急性心肌梗死的影响。方法结扎日本大耳兔冠状动脉左前降支建立急性心肌梗死模型,制模成功后随机分为模型组,丹红注射液低、中、高剂量组及果糖二磷酸钠组,另设假手术组。治疗两周,期间测量不同时间段心肌酶。两周后取心脏进行梗死面积测定。结果各组间心肌酶水平(谷草转氨酶、肌酸激酶同工酶及乳酸脱氢酶)及心肌梗死面积差异无统计学意义,但丹红中剂量组(2ml/kg)心肌酶水平及心肌梗死面积较模型组都有降低或缩小趋势。结论丹红注射液对兔心肌梗死可能有一定的保护作用,但是还需要实验进行证实。Objective To study the effect of Danhong injection on acute myocardial infarction in rabbits. Methods Animal model of acute myocardial infarction was established by ligating the left anterior descending coronary artery of rabbits,then all rabbits were randomly divided into 6 groups that,sham operation,fructose diphosphate,high,middle and low dose of Danhong injection group,and they were treated for two weeks,respectively. The activity of serum aspartate aminotransferase( AST),creatine kinase isoenzyme( CK-MB) and lactate dehydrogenase( LDH) in different time points were examined. The infarction area of the heart was examined after two weeks. Results The difference of cardiac enzymes( AST,CK-MB and LDH) and myocardial infarction area was not statistically significant among 6 groups,but there was a reduction trend for cardiac enzymes and myocardial infarct area in middle dose group( 2ml / kg) of Danhong compared with the control group. Conclusions Danhong injection may have a protective effect on myocardial infarction in rabbits,but the results need to be confirmed in further study.
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