HCV-RNA联合肝功能主要指标对HCV抗体检测阳性者诊断意义的评价  

Investigation for HCV-RNA Combined Liver Function Indexes in Diagnosis of Patients With HCV Antibody Positive

作　　者：陈会枝[1] 

机构地区：[1]郑州大学第一附属医院检验科,450052

出　　处：《中国卫生标准管理》2015年第27期145-147,共3页China Health Standard Management

摘　　要：目的 探究HCV抗体阳性者中HCV抗体值、HCV-RNA载量及肝功能主要指标的关系。方法 回顾分析384名HCV抗体检测阳性者临床检测结果,研究HCV抗体值、HCV-RNA、肝功能主要指标间的关系。结果 HCV抗体值、HCV-RNA载量及肝功能主要指标三者密切相关,HCV抗体检测值在区间1.00~20.00,〉100.00时其HCV-RNA检测阳性率低于抗体检测值在区间20.00~100.00时的HCVRNA检测阳性率,差异有统计学意义（P〈0.05）。随HCV-RNA载量的升高,ALT、AST、GGT、TBIL、DBIL、IBIL检测值平均水平亦升高,差异有统计学意义（P〈0.05）;ALP水平有所增高但程度低于其他指标;而TP、ALB、GLOB平均水平基本无变化。结论 综合HCV抗体值、HCV-RNA载量及肝功能主要指标检测结果可更好地指导HCV感染的临床诊断及治疗。Objective To explore the relationships between HCV antibody levels,HCV-RNA loading and liver function parameters in HCV antibody positive patients. Methods The serum HCV antibody,HCV-RNA loading and liver function parameters of 384 patients were analyzed. Results When HCV antibody level was 1.00 to 20.00 or more than 100.00,the positive rate of HCV-RNA in HCV antibody positive patients was significantly lower than that in the patients with HCV antibody level of 20.00 to 100.00. The difference was statistically significant（P〈0.05）. With increase of HCV-RNA loading,average levels of ALT,AST,GGT,TBIL,DBIL and IBIL increased. The difference was statistically significant（P〈0.05）. The level of ALP increased but not so obviously. Average levels of TP,ALB,GLOB changed little. Conclusion The combination of HCV antibody level,HCV-RNA loading and liver function parameters test conduce to a good understand of clinical diagnosis and treatment of HCV infection.

关 键 词：HCV 抗体 RNA 肝功能 

分 类 号：R446.6[医药卫生—诊断学]