血浆脂蛋白相关磷脂酶A_2及基质金属蛋白酶-9水平与冠脉临界病变斑块特征的关系  

Relationship of matrix metalloproteinases 9,lipoprotein associated phospholipase A_2 and pathological changes of coronary critical patch characteristics

作　　者：赵艳辉[1] 

机构地区：[1]天津市武清区人民医院心内一科,天津301700

出　　处：《临床心血管病杂志》2015年第10期1129-1131,共3页Journal of Clinical Cardiology

摘　　要：冠心病（coronary heart disease,CHD）是由于冠状动脉粥样硬化引起的心脏器质性疾病。炎症反应是促进冠状动脉粥样硬化病变进展的重要因素,使动脉粥样斑块易于破裂、出血,形成血栓,诱发急性心血管事件。研究发现,易损斑块的存在是发生急性冠脉综合征（acute coronary syndrome,ACS）的主要原因。血管内超声（IVUS）能对粥样硬化斑块进行定性分析,从而判断斑块的稳定性。炎症标志物与不稳定斑块的相关性尚不明确。The study by evaluating the stability of coronary heart disease patients of coronary artery plaque and the determination of plasma lipoprotein associated phospholipase A2（LP-PLA2）and matrix metalloproteinases 9（MMP-9）level,Observe the relationships with critical lesions in coronary plaque characteristics.The results showed that there are unstable plaques in coronary borderline lesions,increased plasma concentration of LPPLA2,MMP-9associated with plaque instability.

关 键 词：血浆脂蛋白相关磷脂酶A2 基质金属蛋白酶-9 冠脉临界病变 血管内超声 

分 类 号：R541.4[医药卫生—心血管疾病]