成年早期体重状态及至中年时期体重变化与高甘油三酯血症的相关性研究  

Relationship Between Body Weight Changes From Early Adulthood to Middle Age and the Prevalence of Hypertriglyceridemia by Large-scale Cardiovascular Risk Factor Investigation

作　　者：周龙[1] 李莹[1] 郭敏[1] 田野[1] 武阳丰[2] 赵连成[1] 

机构地区：[1]中国医学科学院北京协和医学院国家心血管病中心阜外医院社区防治部,北京市100037 [2]北京大学公共卫生学院

出　　处：《中国循环杂志》2015年第10期962-966,共5页Chinese Circulation Journal

基　　金：国家"九五"科技攻关计划(96-906-02-01)

摘　　要：目的:探讨成年早期的体重状态及至中年时期的体重变化与中年时期高甘油三酯(TG)血症之间的关系。方法:选取参加1998年我国大规模心血管病危险因素调查的15组人群样本,每个人群整群抽样约1 000人,其年龄在35~59岁(定义为中年时期),男女各半,询问研究对象25岁时(定义为成年早期时)的体重,进行心血管病危险因素调查,根据研究对象25岁时的体重和调查时的身高,计算其25岁时的体重指数(BMI);研究对象成年早期按BMI水平分为4组:低体重组(BMI<18.5 kg/m^2)、正常体重组(BMI:18.5~23.9 kg/m^2)、超重组(BMI:24~27.9 kg/m^2)、和肥胖组(BMI≥28 kg/m^2)。25岁至中年时期的体重变化为现测体重减去25岁时体重,根据体重变化将研究对象分为<-7.5 kg组、-7.5^-2.6 kg组、-2.5~2.5 kg组、2.6~7.5 kg组、7.6~12.5 kg组和>12.5 kg组共6组。分别探讨25岁时的体重状态和随后的体重变化与高TG血症的关系。结果:共有13 883人纳入分析,研究对象按BMI水平的4个分组中年时期高TG血症患病率分别为22.8%、26.0%、27.4%和30.8%,呈明显上升趋势(趋势检验P<0.01)。25岁至中年时期的体重的6组研究对象的高TG血症患病率分别为12.5%、14.0%、17.8%、24.2%、31.5%和40.9%,也呈明显上升趋势(趋势检验P<0.01)。多因素Logistic回归结果显示,25岁时的超重和肥胖以及随后的体重增加均与中年时期高TG血症正相关(趋势检验P<0.01)。结论:成年早期的超重和肥胖以及随后的体重增加均与中年时期罹患高TG血症独立相关。Objective： To explore the relationship between body weight changes from early adulthood to middle age and the prevalence of hypertriglyceridemia by large-scale cardiovascular risk factor investigation. Methods： A total of 15 population groups from China multi-center collaborative study of cardiovascular epidemiology in 1998 were enrolled. There were approximately 1000 participants in each group including 50% of each male and female at the age of （35-59） years which was defined as middle age. The participants were surveyed for cardiovascular risk factors including the body weight and body mass index （BMI） at the age of 25 years which was defined as early adulthood. The participants were divided into 4 groups based on BMI at early adulthood： Low body weight group, BMI 〈 18.5 kg/m2, Normal body weight group, BMI （18.5-23.9） kg/m2, Overweight group, BMI （24-27.9） kg/m2 and Obese group, BMI 〉 28 kg/m2. The changes of body weight from early adulthood to middle age were calculated by body weight at present minus body weight at 25 years; according to the differences, participants were divided into another set of 6 groups： differences 〈 -7.5 kg, （-7.5 to -2.6） kg, （-2.5 to 2.5） kg, （2.6 to7.5） kg, （7.6 to 12.5） kg and 〉 12.5 kg. The relationship between body weight status at 25 years of

关 键 词：体重 肥胖 高甘油三酯血症 

分 类 号：R541[医药卫生—心血管疾病]