白杨素抗氧化应激对实验性糖尿病大鼠脑损伤的保护作用  

Chrysin,an antioxidant molecule,attenuates hyperglycemia-mediated cerebral injury in streptozotocin-induced diabetic rats

作　　者：李洁欣 李倩[1] 李洁[1] 陈敏[1] 田晴晴[1] 张芸芸[2] 张轩萍[1] 

机构地区：[1]山西医科大学药理教研室 [2]山西医科大学第一临床医学院

出　　处：《中国临床药理学与治疗学》2015年第9期967-970,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：山西省自然科学基金(2011011034-3);山西医科大学青年基金(Q02201206)

摘　　要：目的:研究白杨素对大鼠实验性糖尿病脑损伤的影响及其机制。方法:SD大鼠一次性腹腔注射链脲佐菌素(STZ)溶液建立大鼠实验性糖尿病模型,72 h后空腹血糖≥15 mmol/L为模型成功标准。将模型大鼠随机分为模型组和白杨素低、高剂量组(每组10只),另取10只正常大鼠为空白对照组。每周测一次体质量和空腹血糖。4周后禁食12 h麻醉大鼠,采血,取脑组织,测定血清和脑的超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)的活性及丙二醛(MDA)的含量,并且观察脑组织的形态学改变。结果:与模型组比较,白杨素可使血糖降低(P<0.05),同时可减轻脑组织损伤,提高脑内SOD和GSH-Px的活性,降低脑内MDA的含量,差异有统计学意义(P<0.05)。结论:白杨素对实验性糖尿病大鼠脑损伤有保护作用,其机制可能与其具有较强的抗氧化作用有关。AIM： To investigate the beneficial effects of chrysin on cerebral injury induced by hyperglycemia-mediated peroxidation in experimental diabetes mellitus rats. METHODS： The protective effects on hippocampus neuronal damage and antioxidant activities of chrysin at two different doses（ 50,100 mg·kg-1·d-1body weight） were evaluated in rats with streptozotocin（ STZ） induced diabetes mellitus. RESULTS： Induction of diabetes with STZ caused deleterious effects including hyperglycemia,cerebral injury（ hippocampus neuronal damage）,significant elevated lipid peroxidation index（ MDA） and decline in antioxidants（ SOD and GSH-Px）. Chrysin treatment significantly reduced neuronal damage and oxidative changes,and improved the anti-oxidant markers. CONCLUSION：This study indicates an anti-diabetic potential of chrysin,mediated through the modulation of the anti-oxidant defense system. This study suggest that the chrysin supplementation might be beneficial for the attenuation of diabetic complications.

关 键 词：白杨素 糖尿病 氧化应激 抗氧化 

分 类 号：R965.2[医药卫生—药理学]