中西医结合治疗失眠临床疗效观察及其安全性评价  

Clinical Efficacy and Safety Evaluation of Applying Integrative Medicine to Treat Insomnia

作　　者：张祖煌[1] 刘振华[2] 

机构地区：[1]山东大学附属省立医院统计与病案管理科,山东济南250021 [2]山东大学附属省立医院神经内科/山东省睡眠医学中心,山东济南250021

出　　处：《四川中医》2015年第10期57-59,共3页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:观察中西医结合治疗失眠患者临床疗效观察及其安全性。方法:本组95例患者按照随机数字表法随机分为两组,分别为对照组(n=46)和治疗组(n=49)。对照组给予常规西药治疗,治疗组在对照组基础上结合中药汤剂治疗。对比分析两组PSQI各项评分、疗效、主要症状积分、入睡时间和实际睡眠时间及不良反应发生情况。结果:两组睡眠质量、睡眠时间、睡眠障碍、入睡时间、日间功能障碍、睡眠效率及PSQI量表总分治疗后较治疗前显著降低(P<0.05);治疗组睡眠质量、睡眠时间、睡眠障碍、入睡时间、日间功能障碍、睡眠效率及PSQI量表总分治疗后显著低于对照组(P<0.05);治疗组总有效率(89.80%)显著高于对照组(73.91%)(P<0.05);两组患者失眠多梦、心悸胸闷、寐后易惊、胆怯善惊症状积分治疗后较治疗前显著减少(P<0.05);治疗组患者失眠多梦、心悸胸闷、寐后易惊、胆怯善惊症状积分治疗后显著低于对照组(P<0.05);两组入睡时间治疗后显著快于治疗前(P<0.05),实际睡眠时间显著长于治疗前(P<0.05);治疗组入睡时间治疗后显著快于对照组(P<0.05),实际睡眠时间显著长于对照组(P<0.05);治疗期间均未见明显不良反应。结论:中西医结合治疗失眠患者临床疗效显著,安全可靠,具有重要研究价值。Objective： To investigate the clinical efficacy and the safety on insomnia with combination therapy. Methods：95patients in this experiment according to the random number table,randomly divided into two groups,namely the controlled group（ n = 46） and the treatment group（ n = 49）. The controlled group received conventional western medicine,the treatment group received TCM decoction on the basis of the controlled group. Comparing PSQI score,efficacy,major symptom score,sleep time and sleep time and the actual incidence of adverse reactions of the two groups. Results： The quality of sleep,sleep disorders,sleep time,after daytime dysfunction,sleep efficiency and treatment PSQI total score was significantly lower than before treatment（ P〈0. 05）; sleep quality,sleep duration,sleep disorders,sleep time,after daytime dysfunction,sleep efficiency and treatment PSQI total score of the treatment group was significantly lower than the controlled group（ P〈0. 05）; the total efficiency of the treatment group（ 89. 80%） was significantly higher than the controlled group（ 73. 91%）（ P〈0. 05）; the wo groups were insomnia,palpitations,chest tightness,easy to panic after sleep soundly,timid good surprise symptom scores after treatment was lower than before treatment（ P〈0. 05）; patients treated with insomnia,palpitations,chest tightness,sleep soundly after easily frightened,timid good surprise symptom score after treatment was significantly lower than the controlled group（ P〈0. 05）; sleep time after treatment significantly faster than before treatment（ P〈0. 05）,actual sleep time was significantly longer than that before treatment（ P〈0. 05）; treatment group was significantly faster time to fall asleep after treatment in the controlled group（ P〈0. 05）,actual sleep time was significantly longer than the controlled group（ P〈0. 05）; during treatment showed no significant adverse reactions. Conclusion： The clinical curative effect is remarkable of applying combinati

关 键 词：中西医 失眠 疗效 安全性 

分 类 号：R256.23[医药卫生—中医内科学]