多囊卵巢综合征患者血清网膜素水平变化及其意义  

Clinical implications of plasma omentin levels in patients with polycystic ovary syndrome

作　　者：陆新虹[1] 杨海燕[1] 罗佐杰[1] 范余娟[2] 马燕[3] 

机构地区：[1]广西医科大学第一附属医院内分泌科,南宁530021 [2]广西医科大学第一附属医院妇科,南宁530021 [3]广西医科大学第一附属医院超声诊断科,南宁530021

出　　处：《中华内分泌代谢杂志》2015年第10期880-882,共3页Chinese Journal of Endocrinology and Metabolism

基　　金：基金项目：中国糖尿病医生研究方案基金

摘　　要：探讨网膜素（omentin）在多囊卵巢综合征（PCOS）患者血清中的表达，及其与体重指数、胰岛素抵抗的相关性。研究发现对照组、PCOS体重正常组、PCOS超重／肥胖组的血清网膜素浓度有统计学差异[（115．29±33．92）、（111．12±34．50）和（42．85±19．39）pg／ml，P〈0．05]。相关性分析显示PCOS患者网膜素与体重指数、稳态模型评估的胰岛素抵抗指数（HOMA-IR）负相关，多元线性回归显示仅体重指数与网膜素独立相关。网膜素可能通过影响肥胖参与PCOS发病。This paper was to explore the relationship between plasma omentin and obesity and insulin resistance in patients of polycystic ovary syndrome（PCOS）. The results showed that there were statistically significant differences in serum omentin levels among control group, PCOS-normal weight group, and PCOS-overweight group （115.29 ± 33.92）, （111.12 ± 34.50）, and （42.85 ±19.39 ） pg/ml, P 〈0.05 ]. Omentin were negatively correlated with homeostasis model assessment for insulin resistance（HOMA-IR） and body mass index（BMI）. In the multiple stepwise regression analysis, only omentin was negatively correlated with BMI. Omentin may be involved in the development of PCOS by affecting obesity.

关 键 词：多囊卵巢综合征 网膜素 胰岛素抵抗 肥胖症 

分 类 号：R711.75[医药卫生—妇产科学]