慢性精神分裂症血清同型半胱氨酸与认知功能的关系  

Relationship of Serum Homocysteine with Cognitive Function in Chronic Schizophrenia

作　　者：戴新国[1] 叶飞[1] 吴慧[1] 夏旭兰 赵小亚[1] 

机构地区：[1]扬州大学医学院附属五台山医院,扬州225003

出　　处：《中国临床心理学杂志》2015年第5期865-866,864,共3页Chinese Journal of Clinical Psychology

摘　　要：目的:探讨慢性精神分裂症患者血清同型半胱氨酸(homocysteine,Hcy)水平及与神经认知功能的关联。方法:入组符合DSM-IV精神分裂症诊断标准的50例患者,同时入组50名健康志愿者,采用高效液相色谱法测定血清Hcy水平。采用PANSS量表评价患者的临床症状。采用WCST、TMT评价认知功能。结果:患者组血清Hcy水平明显高于对照组。WCST、TMT成绩明显差于对照组。患者组血清Hcy与PANSS量表总分及阴性症状分呈正相关;与WCST正确数呈负相关,与WCST错误总数呈正相关;与TMT-A、TMT-B时间呈正相关。结论:慢性精神分裂症存在明显Hcy异常,血清Hcy与认知功能和阴性症状密切相关,Hcy可能与精神分裂症预后相关。Objective： To explore the relationship between serum homocysteine and cognitive function in chronic schizo-phrenia. Methods： 50 patients meeting the criteria of DSM-IV for schizophrenia and 50 healthy volunteers were recruited.The serum Hcy was determined by HPLC method. The clinical symptoms were assessed by PANSS. WCST、TMT were ad-ministered to evaluate cognitive functions. Results： The serum Hcy levels in schizophrenia group were significantly higherthan control group. The scores of WCST and TMT in schizophrenia group were significantly lower than control group. The se-rum Hcy levels were positively related with PANSS total and negative symptoms scores, total number of WCST errors, thescores of TMT-A and TMT-B, and were negatively related with correct number of WCST in schizophrenia patients. Conclusion： The Hcy abnormality is abnormally increased in chronic schizophrenia patients, which is associated with impairedcognitive function and negative symptom in this severe mental disorder.

关 键 词：精神分裂症 同型半胱氨酸 阴性症状 认知功能 

分 类 号：R395.1[哲学宗教—心理学]