NADPH氧化酶p22phox亚基C242T基因多态性与中国朝鲜族高血压患者左心室肥厚的相关性  

Correlation of NADPH oxidase subunit p22phox gene C242T polymorphism with left ventricular hypertrophy in Chinese Korean hypertensive patients

作　　者：崔敬兰 朴莲善 金光明 

机构地区：[1]延边医院电诊科,吉林省延吉市133000 [2]延边医院内分泌科,吉林省延吉市133000

出　　处：《实用医学杂志》2015年第18期2957-2959,共3页The Journal of Practical Medicine

基　　金：国家自然科学基金(编号:30460053)

摘　　要：目的:探讨NADPH氧化酶p22phox亚基(NADPH oxidase subunit p22phox,NOSP)C242T基因多态性与中国朝鲜族人群原发性高血压(EH)患者发生左心室肥厚(LVH)的相关性。方法:选取正常朝鲜族对照者108例及初诊为EH朝鲜族患者231例,应用聚合酶链反应对所有受试者NOSP 242位点进行基因型分析。231例EH患者再分为EH和EH+LVH组,超声心动图评估患者左心室质量指数,并测定生化指标。结果:NOSP 242位点基因多态性在对照组和EH组中的分布无明显差异;EH组和EH+LVH组中,CC与CT+TT比较,基因分布存在明显差异;CC型EH患者合并LVH的风险高于CT及TT型患者。结论:NOSP C242T基因多态性与朝鲜族EH患者无关。NOSP C242T基因多态性与EH合并LVH相关,CC基因是朝鲜族EH患者合并LVH的风险因素。Objective To investigate the relation between the NOSP gene C242 T polymorphism and Chinese Korean nationality EH patients with LVH. Methods 108 Chinese Korean controls and 231 Chinese Korean EH patients were enrolled in the research.NOSP gene C242 T polymorphism was analyzed by PCR. EH patients were divided into EH and EH ＋LVH group,all of them were evaluated with CDUS for left ventricular mass index. Results The distribution of NOSP gene C242 T polymorphism showed no significant difference compared with controls and EH group.There was significant difference in distribution of CC vs CT ＋TT genotype between EH and EH＋ LVH patients.CC genotype is more dangerous for EH patients combined with LVH than CT and TT genotypes. Conclusions The NOSP gene C242 T polymorphism has no relation with EH in Korean nationality people. The NOSP gene C242 T polymorphism has relation with EH＋LVH; and the CC genotype is a susceptible gene for the Korean EH patients with LVH.

关 键 词：高血压 NADPH氧化酶p22phox亚基 朝鲜族 基因多态性 左心室肥厚 

分 类 号：R544.1[医药卫生—心血管疾病] R540.45[医药卫生—内科学]