转化生长因子-β1基因多态性与上海汉族人群2型糖尿病的相关性  

Association between polymorphism of TGF-β1 gene and type 2 diabetes mellitus in Chinese Han population in Shanghai

作　　者：李俊燕[1] 陶枫[1] 吴新星[2] 谭英姿[1] 贺林[3] 陆灏[1] 

机构地区：[1]上海中医药大学附属曙光医院内分泌科、病研究所、医临床重点实验室,201203 [2]上海电子信息职业技术学院,201411 [3]上海交通大学BIO-X研究院,200030

出　　处：《实用医学杂志》2015年第18期3078-3080,共3页The Journal of Practical Medicine

基　　金：国家自然科学基金(编号:81403359);上海市教育委员会科研创新项目(编号:13YZ042);上海市卫生局(编号:20124076);上海高校青年教师培养资助计划项目(编号:ZZszy12015);上海市中医临床重点实验室(编号:14DZ2273200);上海市中医药事业发展三年行动计划项目(编号:ZYSNXD-CC-YJXYY)

摘　　要：目的：探讨上海汉族人群中转化生长因子-β1（TGF-β1）基因多态性位点T896C与2型糖尿病的关系。方法：采用病例-对照研究设计,以经确诊的1 234例2型糖尿病患者作为病例组,选取1 272例正常健康个体作为对照组。收集研究对照血液标本5 m L,提取全基因组DNA。应用Taqman基因分型技术进行多态性检测。结果：TGF-β1基因T896C位点基因型及等位基因频率分布在病例组和对照组中比较差异均有统计学意义（基因型：P=0.000 1;等位基因：P=0.004,OR=1.18[1.05~1.33]）。结论：TGF-β1基因T896C位点可能与上海汉族人群2型糖尿病具有相关性。Objective To study the association between transforming growth factor- β1（TGF-β1）polymorphism and type 2 diabetes mellitus in Han population of Shanghai. Methods In this case-control study,1 234 cases of T2 DM patients were recruited and 1 272 healthy individuals were selected as control. Five ml of blood sample was collected from each subject,from which the whole genomic DNA was extracted.The polymorphism was detected by the Taqman technology. Result Significant association was observed in TGF-β1 T896 C genotypes and alleles with T2DM（P = 0.0001 and P = 0.004, OR = 1.18 [1.05 ~ 1.33 ], respectively）.Conclusion The polymorphism of T896 C in TGF-β1 gene may be associated with T2 DM in Han population from Shanghai.

关 键 词：糖尿病 2型 多态性 TGF-Β1 

分 类 号：R587.1[医药卫生—内分泌]