四环素可的松眼膏治疗睑板腺功能障碍临床研究  

Study on the treatment of meibomian gland dysfunction with oculentum tetracycline et cortisone

作　　者：王璐璐[1] 祝磊[1] 张月琴[1] 王丽娅[1] 

机构地区：[1]河南省眼科研究所河南省立眼科医院,河南省郑州市450003

出　　处：《中国实用眼科杂志》2015年第10期1119-1122,共4页Chinese Journal of Practical Ophthalmology

基　　金：河南省医学科技攻关计划项目（201403199）

摘　　要：目的观察并评价四环素可的松眼膏局部应用治疗睑板腺功能障碍的安全性及有效性。方法临床病例对照研究。收集2014年2-8月在河南省眼科研究所门诊就诊的睑板腺功能障碍患者84例，分别对每位患者进行眼部症状及体征评价（其中眼部体征评价项目包括结膜充血、泪膜碎屑、睑缘充血、睑板腺开口、睑板腺分泌物）、SchirmerI试验、泪膜破裂时间、角膜荧光素染色、眼压、红外线睑板腺照相、泪液渗透压检查。患者应用数字表法随机分为两组，对照组每天热敷眼睑并每天使用人工泪滴眼液4次。治疗组每天涂抹四环素可的松眼膏于睑缘睑板腺开口处2此，其余方法相同。治疗1个月后复查。结果治疗4周后，两组患者眼部症状及体征评价、SchirmerI试验、泪膜破裂时间、角膜荧光素染色、泪液渗透压检查结果均较治疗前有所改善，差异有统计学意义（P〈0．05）。而睑板腺成像分级评价差异无统计学意义（P〉0．05）。治疗4周后，治疗组患者眼部症状及体征评价、Schirmer I试验、泪膜破裂时间、角膜荧光素染色和泪液渗透压检查结果与对照组比较差异均有统计学意义（P〈0．05）。SchirmerI试验、眼压与治疗前无比较差异无统计学意义（P〉0．05）。结论四环素可的松眼膏局部涂抹于睑缘睑板腺开口处，配合热敷及睑板腺按摩，可明显改善睑板腺功能障碍症状及体征。Objective To observe the efficacy and safety of oculentum tetracycline et cortisone in the treatment of meibomian gland dysfunction. Methods Totally 84 meibomian gland dysfunction patients （168 eyes） enrolled in our hospital from February 2014 to August 2014 were randomly divid- ed into two groups： the experimental group （Oculentum tetracycline et cortisone group） and the con- trol group. Hot compress （2 times/day） and Sodium hyaluronate eye drop （4 times/day） was applied for the patient in the control group. In addition oculentum tetracycline et cortisone was applied 2 times a day for the patient in the experimental group. Questionnaire, slit lamp microscope examination, fluorescent staining, tear break-up time （BUT） and Schirmer I test （Sit） was used in these patients before the treatment and repeated one month after the treatment. The mean of the results were compared by t-tests. Results After 4 weeks of the treatment, the mean score of the questionnaire was significantly lower than that before the treatment in each group （t experimental =5.24, Pexperimental =0.00; t control =4.25, P control =0.00）. And the inflammation of the ocular surface was relieved obviously in both group （t experimental =4.37, P experimental =0,00; t control =3.19, P control =0.002）. BUT was significantly prolonged in each group after the treatment （P 〈0.01）. The mean score of the corneal fluorescein staining （FL） was lower than that before the treatment in each group. There was no significant change in ST I or NCT in each group （P 〉0.05）. Conclusions Topical oculentum tetracycline et cortisone is safe and effective for the treatment of meibomian gland dysfunction.

关 键 词：睑板腺功能障碍 睑缘炎 四环素 治疗 

分 类 号：R927.2[医药卫生—药学]