179例试管婴儿孕妇发生先兆流产的病例对照研究  

Analysis on related factors of 179 cases of pregnant women with threatened abortion occurred in IVF-ET

作　　者：罗桂英[1] 王蒙蒙[2] 王春艳[1] 强昌华 郑金鑫[2] 潘发明[2] 曹云霞[1] 

机构地区：[1]安徽医科大学第一附属医院生殖医学中心,合肥230022 [2]安徽医科大学公共卫生学院,合肥230022

出　　处：《安徽医科大学学报》2015年第11期1634-1638,共5页Acta Universitatis Medicinalis Anhui

基　　金：国家重大科学研究计划(编号:2012CB944704)

摘　　要：目的分析试管婴儿的孕妇发生先兆流产的相关影响因素,为预防试管婴儿孕妇发生先兆流产提供科学依据。方法病例组选取因患先兆流产而住院的孕妇87例;对照组均来自于同期做试管婴儿且无先兆流产的孕妇,共92例,调查试管婴儿孕妇先兆流产的影响因素。应用Epi Data3.1数据库及SPSS 17.0软件进行数据录入及统计分析,分析方法主要包括秩和检验、χ2检验、单因素和多因素条件Logistic回归分析;并计算各影响因素与先兆流产的关联强度（OR值）及其95%CI。结果单因素分析结果表明：两组研究对象的职业、文化程度、身高、体重、体质指数差异无统计学意义（P〉0.05）。但年龄差异有统计学意义（P〈0.05）,两组研究对象在不良妊娠史、既往疾病史、不孕类型、不孕年限方面差异无统计学意义（P〉0.05）;而两组在移植时子宫内膜厚度、移植的胚胎数目、移植胚胎的周期类型、孕妇的焦虑评分显示有统计学意义。多因素条件Logistic回归分析结果显示,胚胎移植时子宫内膜的厚度、移植胚胎的周期类型、妊娠期心理压力是先兆流产发生的独立危险因素（OR=1.169、0.304、0.898,95%CI分别为1.005~1.361、0.135~0.683、0854~0.944）。结论移植时子宫内膜厚度、移植胚胎的周期类型、妊娠期心理压力可能是先兆流产发生的独立危险因素。Objective To analyze the related factors of test tube babies of pregnant women with threatened abortion,and provide scientific basis for prevention of test tube babies of pregnant women with threatened abortion.Methods Patients of the prevalence of threatened abortion pregnant women were admitted to hospital in the same period; control group were from IVF and threatened abortion of pregnant women. The case group 87 cases,control group 92 cases,were selected influence factors investigation in august test tube babies of women with threatened abortion. Double transmission ratio error correction logic input,Epi Data3. 1 and SPSS 17. 0 software were used to input and statistical analysis,methods mainly included signed-rank test,chisquare test,regression analysis,univariate and multivariate Logistic were used; and calculating the strength of association and the influence factors of threatened abortion（ OR value） and 95% CI. Results Univariate analysis results showed that： the two groups had no statistical significance in the study of occupation,education level,height,weight,body mass index（ P〈0. 05）difference. The age difference（ P〉0. 05）,the object of study in adverse pregnancy history,history of disease,type of infertility,infertility duration was not significant; while the two group at the time of transplantation of endometrial thickness,number of embryo transplantation,transplantation of embryonic period,pregnant anxiety scores had statistical significance. Multivariate Logistic regression analysis showed that,at the time of transplantation embryo endometrial thickness,type,the cycle pregnancy psychological pressure was the independent risk factors of threatened abortion（ OR = 1. 169,0. 304,0. 898; 95% CI were 1. 005 - 1. 361,0. 135 - 0. 683,0854- 0. 944）.Conclusion Transplantation of endometrial thickness,embryo transfer cycle,pregnancy psychological stress may be the independent risk factors of threatened abortion.

关 键 词：先兆流产 影响因素 试管婴儿 孕妇 

分 类 号：R714.21[医药卫生—妇产科学]