HIF-1α、Survivin在非小细胞肺癌中的表达  

The expression of HIF-1α and Survivin in human non-small cell lung cancer

作　　者：聂弘 高从荣[1] 赵敏[2] 王瑾[2] 邹强[2] 万军[3] 

机构地区：[1]安徽医科大学附属合肥医院(合肥市第二人民医院)胸心外科,合肥230011 [2]安徽医科大学附属合肥医院(合肥市第二人民医院)病理科,合肥230011 [3]安徽医科大学第一附属医院胸外科,合肥230022

出　　处：《安徽医科大学学报》2015年第11期1674-1676,共3页Acta Universitatis Medicinalis Anhui

基　　金：安徽省自然科学基金(编号:1208085QH159)

摘　　要：目的探讨缺氧诱导因子-1α(HIF-1α)、凋亡相关蛋白Survivin在非小细胞肺癌(NSCLC)中的表达及其与临床病理特征的关系,以及两种蛋白的相关性。方法采用免疫组化法检测52例NSCLC组织及20例癌旁组织中HIF-1α和Survivin的表达。结果 NSCLC组织中Survivin、HIF-1α的阳性表达率分别为69%(36/52)和59%(31/52)均高于癌旁组织。HIF-1α、Survivin的表达与肿瘤临床分期及淋巴结转移病理分级相关(P<0.05)。HIF-1α的表达与Survivin表达(r=0.406,P<0.05)呈正相关。结论在非小细胞肺癌癌组织中HIF-1α、生存素表达明显高于癌旁组织;HIF-1α和Survivin在肿瘤发生、发展过程中存在相互作用并与非小细胞肺癌发展及预后密切相关。Objective To study the expression of hypoxia-inducible factor-1α（ HIF-1α） and Survivin in human non-small cell lung cancer（ NSCLC）,and the relationship between such expression and clinicopathological features of NSCLC. Methods 52 cases of tissue specimen including NSCLC,neighboring noncancerous tissue were collected. These specimens were detected by immunohistochemical methods. Results The expression of HIF-1α and Survivin showed significant difference（ P〈0. 01） between NSCLC tissues and neighboring noncancerous tissues. The positive rates of expression of HIF-1α,Survivin were correlated with the tumor differentiation degree,lymphnode metastasis and tumor stage（ P〈0. 05）,and significant and positive correlation was observed between the positiverate of expression of Survivin and HIF-1α（ P〈0. 05）. Conclusion The overexpression of HIF-1α and Survivin is found in NSCLC. Survivin and HIF-1α may play a synergistic role in the genesis and progression of the malignancy,and there may be a certain synergy between Survivin in the process of tumor occurrence and development.

关 键 词：缺氧诱导因子-1Α 生存素 非小细胞肺癌 

分 类 号：R655.3[医药卫生—外科学]